Results 11 to 20 of about 103,802 (248)
Are there rearrangement hotspots in the human genome? [PDF]
PLoS Computational Biology, 2007 In a landmark paper, Nadeau and Taylor [18] formulated the random breakage model (RBM) of chromosome evolution that postulates that there are no rearrangement hotspots in the human genome.
Max A Alekseyev, Pavel A Pevzner
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Frontiers in GeneticsIntroductionIndividuals with balanced chromosomal rearrangements are at an increased risk for infertility, recurrent miscarriages, and the birth of infants with congenital malformations.
Xiaohang Hu +9 more
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On the Complexity of Some Variations of Sorting by Transpositions [PDF]
Journal of Universal Computer Science, 2020 One of the main challenges in Computational Biology is to find the evolutionary distance between two organisms. In the field of comparative genomics, one way to estimate such distance is to find a minimum cost sequence of rearrangements (large scale ...
Alexsandro Alexandrino +3 more
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Beyond conservation: the landscape of chloroplast genome rearrangements in angiosperms [PDF]
New PhytologistLuiz Augusto Cauz Dos Santos
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Genomic disorders: molecular mechanisms for rearrangements and conveyed phenotypes. [PDF]
PLoS Genetics, 2005 Rearrangements of our genome can be responsible for inherited as well as sporadic traits. The analyses of chromosome breakpoints in the proximal short arm of Chromosome 17 (17p) reveal nonallelic homologous recombination (NAHR) as a major mechanism for ...
James R Lupski, Pawel Stankiewicz
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Genome-wide detection of spontaneous chromosomal rearrangements in bacteria. [PDF]
PLoS ONE, 2012 Genome rearrangements have important effects on bacterial phenotypes and influence the evolution of bacterial genomes. Conventional strategies for characterizing rearrangements in bacterial genomes rely on comparisons of sequenced genomes from related ...
Song Sun +4 more
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Rearrangement Events on Circular Genomes
Bulletin of Mathematical Biology, 2023 AbstractEarly literature on genome rearrangement modelling views the problem of computing evolutionary distances as an inherently combinatorial one. In particular, attention is given to estimating distances using the minimum number of events required to transform one genome into another.
Joshua Stevenson +2 more
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Rearrangement of Noisy Genomes [PDF]
, 2006 Measures of distance between genomic maps are inflated by high levels of noise due to incorrectly resolved paralogy and error at the mapping, sequencing and alignment levels. Comparison is also hampered by lack of information on gene orientation and lack gene order.
Chunfang Zheng, David Sankoff
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Impact of Salmonella genome rearrangement on gene expression
Evolution Letters, 2022 In addition to nucleotide variation, many bacteria also undergo changes at a much larger scale via rearrangement of their genome structure (GS) around long repeat sequences.
Emma V. Waters +4 more
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Large Chromosomal Rearrangements during a Long-Term Evolution Experiment with
mBio, 2014 Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations.
Colin Raeside +10 more
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