Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus
Recombinant strains of hepatitis E virus (HEV) with insertions of human genomic fragments or HEV sequence duplications in the sequence encoding the polyproline region (PPR) were previously described in chronically infected patients.
Sébastien Lhomme +21 more
doaj +1 more source
Ontology for genome comparison and genomic rearrangements
AbstractWe present an ontology for describing genomes, genome comparisons, their evolution and biological function. This ontology will support the development of novel genome comparison algorithms and aid the community in discussing genomic evolution. It provides a framework for communication about comparative genomics, and a basis upon which further ...
Flanagan, K +4 more
openaire +2 more sources
Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier [PDF]
Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death.
Ledesma, Jennifer +21 more
core +1 more source
Genome rearrangement algorithms [PDF]
With the increasing amount of sequenced genomes, a comparison of species based on these data becomes more and more interesting. In contrast to the classical approach, where only point mutations were considered, genome rearrangement problems ignore small mutations and only consider large-scale mutations that change the gene order on the chromosomes ...
openaire +1 more source
Rearrangement analysis of multiple bacterial genomes
Background Genomes are subjected to rearrangements that change the orientation and ordering of genes during evolution. The most common rearrangements that occur in uni-chromosomal genomes are inversions (or reversals) to adapt to the changing environment.
Mehwish Noureen +3 more
doaj +1 more source
Addition of the microchromosome GGA25 to the chicken genome sequence assembly through radiation hybrid and genetic mapping [PDF]
BACKGROUND: The publication of the first draft chicken sequence assembly became available in 2004 and was updated in 2006. However, this does not constitute a definitive and complete sequence of the chicken genome, since the microchromosomes are ...
Gourichon, David +65 more
core +1 more source
Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea [PDF]
Background: Brassica oleracea is a valuable vegetable species that has contributed to human health and nutrition for hundreds of years and comprises multiple distinct cultivar groups with diverse morphological and phytochemical attributes.
John Nixon +83 more
core +1 more source
Inversions maintain differences between migratory phenotypes of a songbird
Rearrangements in the genome are important for local adaptation and speciation but are often difficult to identify reliably. Here the authors show that rearrangements underlie large chromosome regions that separate differentially migratory willow ...
Max Lundberg +3 more
doaj +1 more source
Background The ability of bacteria to acquire resistance to antibiotics relies to a large extent on their capacity for genome modification. Prokaryotic genomes are highly plastic and can utilize horizontal gene transfer, point mutations, and gene ...
Marloes Hoeksema +4 more
doaj +1 more source
Genome-wide tests for introgression between cactophilic Drosophila implicate a role of inversions during speciation [PDF]
K.L. was funded by a junior research fellowship from the National Environmental Research Council, UK (NE/I020288/1, NBAF659).Models of speciation-with-gene-flow have shown that the reduction in recombination between alternative chromosome arrangements ...
Etges, William J +9 more
core +1 more source

