Results 51 to 60 of about 11,679 (258)

Implicit Transpositions in DCJ Scenarios

Frontiers in Genetics, 2017
Genome rearrangements are large-scale evolutionary events that shuffle genomic architectures. The minimal number of such events between two genomes is often used in phylogenomic studies to measure the evolutionary distance between the genomes. Double-Cut-
Pavel Avdeyev, Shuai Jiang, Max A. Alekseyev   +2 more
doaj   +1 more source

A pipeline for complete characterization of complex germline rearrangements from long DNA reads

Genome Medicine, 2020
Background Many genetic/genomic disorders are caused by genomic rearrangements. Standard methods can often characterize these variations only partly, e.g., copy number changes or breakpoints.
Satomi Mitsuhashi, Sachiko Ohori, Kazutaka Katoh, Martin C. Frith, Naomichi Matsumoto   +4 more
doaj   +1 more source

Recombination-mediated genome rearrangements

Current Opinion in Genetics & Development, 2021
Homologous recombination (HR) is a universal DNA double-strand break (DSB) repair pathway that uses an intact DNA molecule as a template. Signature HR reactions are homology search and DNA strand invasion catalyzed by the prototypical RecA-ssDNA filament (Rad51 and Dmc1 in eukaryotes), which produces heteroduplex DNA-containing joint molecules (JMs ...
Savocco, Jérôme, Piazza, Aurèle
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Transcription is a major driving force for plastid genome instability in Arabidopsis.

PLoS ONE, 2019
Though it is an essential process, transcription can be a source of genomic instability. For instance, it may generate RNA:DNA hybrids as the nascent transcript hybridizes with the complementary DNA template. These hybrids, called R-loops, act as a major
Juliana Andrea Pérez Di Giorgio, Étienne Lepage, Samuel Tremblay-Belzile, Sébastien Truche, Audrey Loubert-Hudon, Normand Brisson   +5 more
doaj   +1 more source

A SNP based linkage map of the turkey genome reveals multiple intrachromosomal rearrangements between the Turkey and Chicken genomes [PDF]

, 2010
Background The turkey (Meleagris gallopavo) is an important agricultural species that is the second largest contributor to the world's poultry meat production.
Bastiaansen John WM, Vereijken, A., Martien AM Groenen, Aslam Muhammad L, Groenen, M.A.M., John WM Bastiaansen, Bastiaansen, J.W.M., Hendrik-Jan Megens, Muhammad L Aslam, Richard PMA Crooijmans, Addie Vereijken, Vereijken Addie, Crooijmans, R.P.M.A., Groenen Martien AM, Crooijmans Richard PMA, Megens, H.J.W.C., Aslam, M.L., Megens Hendrik-Jan   +17 more
core   +1 more source

A Maximum Parsimony Principle for Multichromosomal Complex Genome Rearrangements [PDF]

, 2022
Motivation. Complex genome rearrangements, such as chromothripsis and chromoplexy, are common in cancer and have also been reported in individuals with various developmental and neurological disorders. These mutations are proposed to involve simultaneous
Simonaitis, Pijus, Raphael, Benjamin J., Raphael, Benjamin J   +2 more
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

On the weight of indels in genomic distances

, 2011
Dias Vieira Braga M, Machado R, Ribeiro LC, Stoye J. On the weight of indels in genomic distances. BMC Bioinformatics. 2011;12(Suppl 9: RECOMB-CG 2011): S13.Background: Classical approaches to compute the genomic distance are usually limited to genomes ...
Machado, Raphael, Stoye, Jens ; https://orcid.org/, Dias Vieira Braga, Marília, Ribeiro, Leonardo C.   +3 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source