Results 71 to 80 of about 11,679 (258)
TFIIS-Dependent Non-coding Transcription Regulates Developmental Genome Rearrangements. [PDF]
PLoS Genetics, 2015 Because of their nuclear dimorphism, ciliates provide a unique opportunity to study the role of non-coding RNAs (ncRNAs) in the communication between germline and somatic lineages.
Kamila Maliszewska-Olejniczak +8 more
doaj +1 more source
The Complete Mitochondrial Genome of the Geophilomorph Centipede Strigamia maritima.
, 2015 Strigamia maritima (Myriapoda; Chilopoda) is a species from the soil-living order of geophilomorph centipedes. The Geophilomorpha is the most speciose order of centipedes with over a 1000 species described.
Maximilian J Telford +15 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
mSphere, 2020 Most of our knowledge relating to molecular mechanisms of human fungal pathogenesis in Candida albicans relies on reverse genetics approaches, requiring strain engineering. DNA-mediated transformation of C. albicans has been described as highly mutagenic,
Timea Marton +3 more
doaj +1 more source
Deciphering complex breakage-fusion-bridge genome rearrangements with Ambigram
Nature Communications, 2023 Breakage-fusion-bridge (BFB) is a complex rearrangement that leads to tumor malignancy. Existing models for detecting BFBs rely on the ideal BFB hypothesis, ruling out the possibility of BFBs entangled with other structural variations, that is, complex ...
Chaohui Li +4 more
doaj +1 more source
ParIS Genome Rearrangement server [PDF]
Bioinformatics, 2004 Abstract Summary: ParIS Genome Rearrangement is a web server for a Bayesian analysis of unichromosomal genome pairs. The underlying model allows inversions, transpositions and inverted transpositions. The server generates a Markov chain using a Partial Importance Sampler technique, and samples trajectories of mutations from this chain ...
Miklós, I, Ittzés, P, Hein, J
openaire +2 more sources
Chromosome rearrangements and population genomics [PDF]
, 2023 Chromosome rearrangements result in changes to the physical linkage and order of sequences in the genome. Although we have known about these mutations for more than a century, we still lack a detailed understanding of how they become fixed and what ...
Mackintosh, Alexander
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae
Nature CommunicationsSynthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements. However, the potential of SCRaMbLE to study genomic rearrangements is currently hindered, because a strain ...
Li Cheng +15 more
doaj +1 more source
Complexity and Enumeration in Models of Genome Rearrangement
Theoretical Computer Science, 2023 Full version of paper that appeared in COCOON 2023: https://doi.org/10.1007/978-3-031-49190 ...
Lora Bailey +10 more
openaire +3 more sources