Results 61 to 70 of about 11,679 (258)

Reconstructing cancer genomes from paired-end sequencing data

BMC Bioinformatics, 2012
Background A cancer genome is derived from the germline genome through a series of somatic mutations. Somatic structural variants - including duplications, deletions, inversions, translocations, and other rearrangements - result in a cancer genome that ...
Oesper Layla, Ritz Anna, Aerni Sarah J, Drebin Ryan, Raphael Benjamin J   +4 more
doaj   +1 more source

On the similarity of sets of permutations and its applications to genome comparison

, 2003
Bergeron A, Stoye J. On the similarity of sets of permutations and its applications to genome comparison. In: Proc. of COCOON 2003. LNCS. Vol 2697.
Jens Stoye, Bergeron, Anne, Stoye, Jens ; https://orcid.org/, Anne Bergeron   +3 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Genome plasticity in Candida albicans is driven by long repeat sequences

eLife, 2019
Genome rearrangements resulting in copy number variation (CNV) and loss of heterozygosity (LOH) are frequently observed during the somatic evolution of cancer and promote rapid adaptation of fungi to novel environments.
Robert T Todd, Tyler D Wikoff, Anja Forche, Anna Selmecki   +3 more
doaj   +1 more source

The Paramecium histone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements.

PLoS Genetics, 2020
In Paramecium tetraurelia, a large proportion of the germline genome is reproducibly removed from the somatic genome after sexual events via a process involving small (s)RNA-directed heterochromatin formation and DNA excision and repair.
Augustin de Vanssay, Amandine Touzeau, Olivier Arnaiz, Andrea Frapporti, Jamie Phipps, Sandra Duharcourt   +5 more
doaj   +1 more source

Frequent spontaneous structural rearrangements promote rapid genome diversification in a Brassica napus F1 generation

Frontiers in Plant Science, 2022
In a cross between two homozygous Brassica napus plants of synthetic and natural origin, we demonstrate that novel structural genome variants from the synthetic parent cause immediate genome diversification among F1 offspring.
Mauricio Orantes-Bonilla, Manar Makhoul, HueyTyng Lee, Harmeet Singh Chawla, Paul Vollrath, Anna Langstroff, Fritz J. Sedlazeck, Jun Zou, Rod J. Snowdon   +8 more
doaj   +1 more source

Mitochondrial Genomic Rearrangements in Songbirds [PDF]

Molecular Biology and Evolution, 2000
The organization of the mitochondrial genome is generally very conserved among vertebrates. Because of this, examination of the rare rearrangements which do occur has been suggested as offering a powerful alternative to phylogenetic analyses of mitochondrial DNA sequences.
S, Bensch, A, Härlid
openaire   +2 more sources

BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons [PDF]

, 2011
Background Visualisation of genome comparisons is invaluable for helping to determine genotypic differences between closely related prokaryotes. New visualisation and abstraction methods are required in order to improve the validation, interpretation and
Beatson, SA, Beatson Scott A, Nabil-Fareed Alikhan, Ben Zakour, Nouri L., Beatson, Scott A., Petty, NK, Nicola K Petty, Petty Nicola K, Alikhan Nabil-Fareed, Alikhan, Nabil-Fareed, Petty, Nicola K., Ben Zakour, NL, Scott A Beatson, Alikhan, NF, Nouri L Ben Zakour, Ben Zakour Nouri L   +15 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Decoding genomic rearrangements for cancer driver discovery

Molecules and Cells
: Somatically acquired genomic rearrangements are common genomic alterations that contribute to malignancy by altering the expression or activity of cancer-related genes in human cancer.
Enyoung Seo, Sooyeon Park, Inho Park, Jinhyuk Bhin   +3 more
doaj   +1 more source