Results 101 to 110 of about 11,679 (258)

Recombination and population structure in salmonella enterica [PDF]

, 2011
Salmonella enterica is a bacterial pathogen that causes enteric fever and gastroenteritis in humans and animals. Although its population structure was long described as clonal, based on high linkage disequilibrium between loci typed by enzyme ...
Street, T, Bowden, R., Anjum, Muna F., Xavier Didelot, Falush Daniel, Donnelly Peter, Didelot, X., Anjum, MF, Donelly, P., McVean, G., Gil McVean, Vartul Sangal, Didelot, X, Bowden, Rory, Anjum Muna F., Donnelly, Peter, Anjum, Muna, Achtman, Mark, Sangal, V, Spencer, C., Falush, Daniel, Muna F. Anjum, Sangal, V., Tanya Golubchik, Anjum, M., Achtman, M., Daniel Falush, Peter Donnelly, McVean, G, Didelot, Xavier, Teresa Street, Mark Achtman, Bowden Rory, Spencer, Chris, Didelot Xavier, Sangal, Vartul, Street, T., Spencer Chris, McVean Gil, Spencer, C, Donelly, Peter, Chris Spencer, Donnelly, P, Street, Teresa, Street Teresa, Golubchik Tanya, Golubchik, T., Achtman Mark, Golubchik, Tanya, Falush, D, Rory Bowden, Bowden, R, McVean, Gilean, Sangal Vartul, McVean, Gil, Golubchik, T, Falush, D. ; https://orcid.org/, Muna F Anjum, Achtman, M   +58 more
core   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Transient multifocal genomic crisis creating chromothriptic and non-chromothriptic rearrangements in prezygotic testicular germ cells

BMC Medical Genomics, 2019
Background The co-occurrence of multiple de novo copy number variations (CNVs) is a rare phenomenon in the human genome. Recently, an “organismal CNV mutator phenotype” has been reported to result in transient genomic instability introducing multiple de ...
Atsushi Hattori, Kohji Okamura, Yumiko Terada, Rika Tanaka, Yuko Katoh-Fukui, Yoichi Matsubara, Keiko Matsubara, Masayo Kagami, Reiko Horikawa, Maki Fukami   +9 more
doaj   +1 more source

CNV and nervous system diseases - what's new? [PDF]

, 2008
Several new genomic disorders caused by copy number variation (CNV) of genes whose dosage is critical for the physiological function of the nervous system have been recently identified.
Gu, W., Lupski, J. R.
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Occurrence, plasticity and evolution of the vpma gene family, a genetic system devoted to high frequency surface variation in Mycoplasma agalactiae [PDF]

, 2009
Mycoplasma agalactiae, an important pathogen of small ruminants, exhibits a very versatile surface architecture by switching ON-OFF multiple, related lipoproteins (Vpmas).
Glew, Michelle, Nouvel, Laurent-Xavier, Sirand-Pugnet, Pascal, Mangenot, Sophie, Barbe, Valérie, Claverol, Stéphane, Sagné, Eveline, Barré, Aurélien, Citti, Christine, Marenda, Marc   +9 more
core   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Estimating true evolutionary distances under rearrangements, duplications, and losses

BMC Bioinformatics, 2010
Background The rapidly increasing availability of whole-genome sequences has enabled the study of whole-genome evolution. Evolutionary mechanisms based on genome rearrangements have attracted much attention and given rise to many models; somewhat ...
Moret Bernard ME, Swenson Krister M, Rajan Vaibhav, Lin Yu   +3 more
doaj   +1 more source

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

, 2019
Whole-genome sequencing using massively parallel sequencing technologies enables accurate detection of somatic rearrangements in cancer. Pinpointing large numbers of rearrangement breakpoints to base-pair resolution allows analysis of rearrangement ...
Meyerson, Matthew, Lawrence, Michael S., Stewart, Chip, Gabriel, Stacey B., Lander, Eric S., Drier, Yotam, Beroukhim, Rameen, Getz, Gad, Carter, Scott L.   +8 more
core   +1 more source