Results 91 to 100 of about 1,157,209 (319)

Complete genome sequence of Borrelia afzelii K78 and comparative genome analysis.

PLoS ONE, 2015
The main Borrelia species causing Lyme borreliosis in Europe and Asia are Borrelia afzelii, B. garinii, B. burgdorferi and B. bavariensis. This is in contrast to the United States, where infections are exclusively caused by B. burgdorferi.
Wolfgang Schüler, Ignas Bunikis, Jacqueline Weber-Lehman, Pär Comstedt, Sabrina Kutschan-Bunikis, Gerold Stanek, Jutta Huber, Andreas Meinke, Sven Bergström, Urban Lundberg   +9 more
doaj   +1 more source

Genome sequencing and annotation of Proteus sp. SAS71

Genomics Data, 2015
We report draft genome sequence of Proteus sp. strain SAS71, isolated from water spring in Aljouf region, Saudi Arabia. The draft genome size is 3,037,704 bp with a G + C content of 39.3% and contains 6 rRNA sequence (single copies of 5S, 16S & 23S rRNA).
Samy Selim, Sherif Hassan, Nashwa Hagagy
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Complete Genome Sequence of Pseudoxanthomonas taiwanensis AL17 and its Potential Genes

Journal of Pure and Applied Microbiology
Several reports on genome sequencing using Next Generation Sequencing (NGS) to identify the total genome were extensively carried out; however, genome identification on thermophilic microorganisms is still limited.
Deviyanthi Nur Afifah, Leyla Novita Brigiyanti, Made Puspasari Widhiastuty, Elvi Restiawaty, Akhmaloka   +4 more
doaj   +1 more source

Hypergraph covering problems motivated by genome assembly questions [PDF]

arXiv, 2013
The Consecutive-Ones Property (C1P) is a classical concept in discrete mathematics that has been used in several genomics applications, from physical mapping of contemporary genomes to the assembly of ancient genomes. A common issue in genome assembly concerns repeats, genomic sequences that appear in several locations of a genome.
arxiv  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Genome-wide SNP identification by high-throughput sequencing and selective mapping allows sequence assembly positioning using a framework genetic linkage map

BMC Biology, 2010
Background Determining the position and order of contigs and scaffolds from a genome assembly within an organism's genome remains a technical challenge in a majority of sequencing projects. In order to exploit contemporary technologies for DNA sequencing,
Xu Xiangming, Sargent Daniel J, Christoffels Alan, Celton Jean-Marc, Rees D Jasper G   +4 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Characteristics of the a sequence of the duck Plague virus genome and specific cleavage of the viral genome based on the a sequence

Veterinary Research
During the replication process, the herpesvirus genome forms the head-to-tail linked concatemeric genome, which is then cleaved and packaged into the capsid.
Qiao Yang, Yaya Feng, Yuanxin Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Ying Wu, Shaqiu Zhang, Bin Tian, Xumin Ou, Sai Mao, Juan Huang, Qun Gao, Di Sun, Zhen Wu, Yu He, Ling Zhang, Yanling Yu, Anchun Cheng   +21 more
doaj   +1 more source

Ultraconserved Sequences in the Honeybee Genome - Are GC-rich Regions Preferred? [PDF]

Systemix Reports 2, Feb. 18 (2007), 2007
Among all insect genomes, honeybee displays one of the most unusual patterns with interspersed long AT and GC-rich segments. Nearly 75% of the protein-coding genes are located in the AT-rich segments of the genome, but the biological significance of the GC-rich regions is not well understood.
arxiv