Results 91 to 100 of about 5,201,388 (369)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

De novo assembly of the carrot mitochondrial genome using next generation sequencing of whole genomic DNA provides first evidence of DNA transfer into an angiosperm plastid genome

BMC Plant Biology, 2012
Background Sequence analysis of organelle genomes has revealed important aspects of plant cell evolution. The scope of this study was to develop an approach for de novo assembly of the carrot mitochondrial genome using next generation sequence data from ...
Iorizzo Massimo, Senalik Douglas, Szklarczyk Marek, Grzebelus Dariusz, Spooner David, Simon Philipp   +5 more
doaj   +1 more source

PacBio assembly of a Plasmodium knowlesi genome sequence with Hi-C correction and manual annotation of the SICAvar gene family. [PDF]

, 2018
Plasmodium knowlesi has risen in importance as a zoonotic parasite that has been causing regular episodes of malaria throughout South East Asia. The P. knowlesi genome sequence generated in 2008 highlighted and confirmed many similarities and differences
Ay, F, Batugedara, G, Chien, J-T, DeBARRY, JD, Galinski, MR, Geraldo, JA, Humphrey, J, Kissinger, JC, Lapp, SA, Le Roch, KG, MaHPIC consortium, Pakala, SB   +11 more
core  

Complete genome sequence of Meiothermus silvanus type strain (VI-R2). [PDF]

, 2010
Meiothermus silvanus (Tenreiro et al. 1995) Nobre et al. 1996 belongs to a thermophilic genus whose members share relatively low degrees of 16S rRNA gene sequence similarity.
Bristow, James, Chang, Yun-Juan, Chen, Amy, Cheng, Jan-Fang, Copeland, Alex, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Han, Cliff, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Land, Miriam, Lapidus, Alla, Liolios, Konstantinos, Lowry, Stephen, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Mikhailova, Natalia, Nolan, Matt, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Rohde, Manfred, Sikorski, Johannes, Tice, Hope, Tindall, Brian J, Woyke, Tanja   +32 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Genome sequence of Acetomicrobium hydrogeniformans OS1 [PDF]

, 2018
Acetomicrobium hydrogeniformans, an obligate anaerobe of the phylum Synergistetes, was isolated from oil production water. It has the unusual ability to produce almost 4 molecules H2/molecule glucose. The draft genome of A.
Cook, Lauren E, Gang, Spencer S, Gunsalus, Robert P, Ihlan, Alicia, Lobos, Elizabeth A, Maune, Matthew, McInerney, Michael J, Tanner, Ralph S, Weinstock, George   +8 more
core   +2 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Gene duplication and paleopolyploidy in soybean and the implications for whole genome sequencing

BMC Genomics, 2007
Background Soybean, Glycine max (L.) Merr., is a well documented paleopolyploid. What remains relatively under characterized is the level of sequence identity in retained homeologous regions of the genome.
Nelson Rex T, Roe Bruce A, O'Bleness Majesta, Yi Jing, Deshpande Shweta, Vasylenko-Sanders Iryna F, Schlueter Shannon D, Lin Jer-Young, Schlueter Jessica A, Scheffler Brian E, Jackson Scott A, Shoemaker Randy C   +11 more
doaj   +1 more source

Whole genome sequence of a Turkish individual. [PDF]

PLoS ONE, 2014
Although whole human genome sequencing can be done with readily available technical and financial resources, the need for detailed analyses of genomes of certain populations still exists.
Haluk Dogan, Handan Can, Hasan H Otu
doaj   +1 more source