Results 91 to 100 of about 1,856,648 (340)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Characteristics of the a sequence of the duck Plague virus genome and specific cleavage of the viral genome based on the a sequence

Veterinary Research
During the replication process, the herpesvirus genome forms the head-to-tail linked concatemeric genome, which is then cleaved and packaged into the capsid.
Qiao Yang, Yaya Feng, Yuanxin Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Ying Wu, Shaqiu Zhang, Bin Tian, Xumin Ou, Sai Mao, Juan Huang, Qun Gao, Di Sun, Zhen Wu, Yu He, Ling Zhang, Yanling Yu, Anchun Cheng   +21 more
doaj   +1 more source

Complete genome sequences of four isolates of Citrus leaf blotch virus from citrus in China

Journal of Integrative Agriculture, 2018
Citrus leaf blotch virus (CLBV) is a member of the genus Citrivirus, in the family Betaflexiviridae. It has been reported CLBV could infect kiwi, citrus and sweet cherry in China.
Ping LI, Min LI, Song ZHANG, Jun WANG, Fang-yun YANG, Meng-ji CAO, Zhong-an LI   +6 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Complete genome sequence of Borrelia afzelii K78 and comparative genome analysis.

PLoS ONE, 2015
The main Borrelia species causing Lyme borreliosis in Europe and Asia are Borrelia afzelii, B. garinii, B. burgdorferi and B. bavariensis. This is in contrast to the United States, where infections are exclusively caused by B. burgdorferi.
Wolfgang Schüler, Ignas Bunikis, Jacqueline Weber-Lehman, Pär Comstedt, Sabrina Kutschan-Bunikis, Gerold Stanek, Jutta Huber, Andreas Meinke, Sven Bergström, Urban Lundberg   +9 more
doaj   +1 more source

Complete genome sequence of Bacillus amyloliquefaciens YP6, a plant growth rhizobacterium efficiently degrading a wide range of organophosphorus pesticides

Journal of Integrative Agriculture, 2019
Bacillus amyloliquefaciens YP6, a plant growth promoting rhizobacteria, is capable of efficiently degrading a wide range of organophosphorus pesticides (OPs).
Di MENG, Li-xin ZHAI, Qiao-peng TIAN, Zheng-bing GUAN, Yu-jie CAI, Xiang-ru LIAO   +5 more
doaj   +1 more source

Replication Data for: Draft genome sequence data of Nothopassalora personata from Argentina

, 2023
Cinthia Conforto
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Complete Genome Sequence of Pseudoxanthomonas taiwanensis AL17 and its Potential Genes

Journal of Pure and Applied Microbiology
Several reports on genome sequencing using Next Generation Sequencing (NGS) to identify the total genome were extensively carried out; however, genome identification on thermophilic microorganisms is still limited.
Deviyanthi Nur Afifah, Leyla Novita Brigiyanti, Made Puspasari Widhiastuty, Elvi Restiawaty, Akhmaloka   +4 more
doaj   +1 more source

First detection and complete genome of Soybean chlorotic mottle virus naturally infecting soybean in China by deep sequencing

Journal of Integrative Agriculture, 2019
Soybean chlorotic mottle virus (SbCMV) was first detected from soybean plants in Jiangxi Province of China by high throughput sequencing and was confirmed by PCR.
Qian-qian HU, Xue-jian LIU, Xue-dong HAN, Yong LIU, Jun-xi JIANG, Yan XIE   +5 more
doaj   +1 more source