Results 71 to 80 of about 3,470,657 (312)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic Human African Trypanosomiasis [PDF]

, 2010
<p><b>Background:</b> <i>Trypanosoma brucei gambiense</i> is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central ...
Martin A Aslett, Hertz-Fowler Christiane, Chukualim, B., Gibson, W., Melville, S.E., Jackson Andrew P., Jackson, A.P., Jackson, A., Capewell, P., Sanders Mandy, Annette MacLeod, McQuillan, J, Quail, M.A., MacLeod Annette, Melville Sara E., Melville, S., McQuillan, J., Paul Capewell, Aslett Martin A., Bridget Chukualim, MacLeod, A., Aslett, M., Hertz-Fowler, C., McQuillan Jacqueline, Aslett, M.A., Mandy Sanders, Berry Andrew, Michael A Quail, Barry, J.D., Berriman, M., Sanders, M., Wendy Gibson, Sara E Melville, Jacqueline McQuillan, Gibson, WC, Quail Michael A., Berry, A., J David Barry, Andrew P Jackson, Andrew Berry, Christiane Hertz-Fowler, Matthew Berriman, Chukualim Bridget, Gibson Wendy, Barry J. David, Capewell Paul, Berriman Matthew   +46 more
core   +1 more source

Comparison of gene fusion detection algorithms reveals frequently overlooked driver fusions in hematologic malignancies

npj Precision Oncology
Accurate detection of driver gene fusions is essential for the diagnosis, treatment, and prognostic prediction of hematologic malignancies. Despite increasing reliance on RNA sequencing (RNA-seq) for fusion detection, its algorithms have not been ...
Zen Tamura, Yuki Saito, Yasunori Kogure, Yuji Oshikawa-Kumade, Suguru Fukuhara, Sumito Shingaki, Hirokazu Kariyazono, Yoshiya Kikukawa, Yuta Ito, Kota Mizuno, Yuichi Shiraishi, Kotoe Katayama, Seiya Imoto, Koji Izutsu, Koichi Murakami, Junji Koya, Keisuke Kataoka   +16 more
doaj   +1 more source

Chloroplast genome of the wild tuber-bearing diploid potato relative Solanum chacoense

Mitochondrial DNA. Part B. Resources, 2017
Solanum chacoense is a wild tuber-bearing species belonging to Solanaceae family. The chloroplast genome of the species was completed by de novo assembly using a small amount of whole genome sequencing data. The genome is the circular DNA molecule with a
Kwang-Soo Cho, Jang-Gyu Choi, Ji-Hong Cho, Ju-Sung Im, Young-Eun Park, Su-Young Hong, Tae-Ho Park   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Sequencing the regulatory genome [PDF]

Genome Biology, 2008
A report on the Cold Spring Harbor Laboratory meeting 'Systems Biology: Global Regulation of Gene Expression', Cold Spring Harbor, USA, 27-30 March 2008.
Aerts, Stein, Butland, Stefanie
openaire   +2 more sources

Complete genome sequence data for

Data in Brief
We present whole-genome sequence data for the Klebsiella pneumoniae strain KAB03, isolated from Ready-To-Eat Vegetable Salads in Kampala District, Central Uganda. Genomic DNA was extracted and sequenced using the Illumina platform.
Abubaker Kawooya, Chinyere Nkemjika Anyanwu, Emmanuel Eilu, Hussein Kafeero, Adam Ahmed Adam, Mariam Oyedeji Amusa, Danladi Makeri, Martin Odoki, Rasheed Omotayo Adeyemo, Michael Ben Okon, Ismail Abiola Adebayo, Saheed Adekunle Akinola   +11 more
doaj   +1 more source

Complete chloroplast genome sequence of the wild diploid potato relative, Solanum brevicaule

Mitochondrial DNA. Part B. Resources, 2019
Solanum brevicaule is a wild tuber-bearing species belonging to Solanaceae family. The complete chloroplast genome of S. brevicaule was constituted by de novo assembly using a small amount of whole genome sequencing data.
Tae-Ho Park
doaj   +1 more source

The complete chloroplast genome sequence of the Alstroemeria hybrid variety ‘Hanhera’

Mitochondrial DNA. Part B. Resources, 2020
Alstroemeria, a member of the Alstroemeriaceae family, is a species from South America. The chloroplast genome of Alstroemeria spp. was completed by de novo assembly using a small amount of whole genome sequencing data.
Jong-Bo Kim, Hwan-Rae Yang, Sang-Hee Lee, Tae-Ho Park   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source