Results 121 to 130 of about 3,470,657 (312)
Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk +17 morewiley +1 more sourceGenome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle [PDF]
, 2015 Background
Domestication of the now-extinct wild aurochs, Bos primigenius, gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus.Magee, DA, Murphy, A., Lohan, AJ, Braud, Martin, Rue-Albrecht, K, Edwards, C.J., Schroeder, Steven, Park, S.D.E., Teasdale, Matthew D., McGettigan, Paul A., Mark, Donoghue, Braud, M, Murphy, Alison, Chamberlain, AT, Bradley, D.G., Chamberlain, Andrew, Liu, Yuan, McGettigan, PA, Lohan, A.J., Spillane, C, Magee, David A., Sonstegard, Tad S., Tai, S, Liu, Y, MacHugh, DE, Murphy, A, School of Earth and Environmental Sciences, Schroeder, S, Tai, Shuaishuai, Bradley, Daniel G., Spillane, Charles, Donaghue, M.T., Park, SD, Braud, M., Loftus, Brendan J., Park, Stephen D E, Chamberlain, Andrew T., Loftus, BJ, MacHugh, David E., Park, Stephen D. E., Bradley, DG, Donoghue, Mark T., Lohan, Amanda J., Teasdale, M.D., Liu, Y., McGettigan, P.A., Teasdale, MD, Magee, D.A., Sonstegard, TS, Donoghue, MT, Edwards, CJ, University of Dublin Trinity College, Rue-Albrecht, Kévin, Chamberlain, A.T., Edwards, Ceiridwen J. +54 morecore +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceComplete genome sequence of Rhizobium leguminosarum bv. trifolii strain WSM1325, an effective microsymbiont of annual Mediterranean clovers [PDF]
, 2010 Rhizobium leguminosarum bv trifolii is a soil-inhabiting bacterium that has the capacity to be an effective nitrogen fixing microsymbiont of a diverse range of annual Trifolium (clover) species.Alex Copeland, John Howieson, Mavromatis, K, Cliff Han, Nolan, M, Victor Markowitz, Nandasena, K.G., Konstantinos Mavromatis, Ovchinikova, G, Lambert Bräu, Natalia Ivanova, Ardley, J.K., Wayne Reeve, Ardley, J, Patrick Chain, Bräu, L, Melino, V, Denton, M., Chain, P., Nandesena, K, Yates, R, Copeland, A., Melino, V., Ivanova, N, Ravi Tiwari, Ivanova, N., Graham O’Hara, Nandesena, K., O'Hara, G, Yates, R.J., Yates, R., Julie Ardley, Brettin, T., Kyrpides, N., Copeland, A, et al., Markowitz, V., Vanessa Melino, Reeve, W.G., O'Hara, G.W., Nolan, M., Miriam Land, Han, Cliff, Matthew Denton, Tiwari, R., Nikos Kyrpides, Matt Nolan, Thomas Brettin, Tiwari, R, Reeve, W., Han, C, Han, C., Reeve, W, Land, M., O'Hara, G., Ron Yates, Denton, M, Kemanthi Nandesena, Howieson, J, Mavromatis, K., Ardley, J., Galina Ovchinikova, Chain, P, Kyrpides, N, Ovchinikova, G., Land, M, Brettin, T, Howieson, J., Markowitz, V, Bräu, L., Yates, Ronald J, Chain, Patrick, Tiwari, Ravi P, Ovchinikova, Galina, Kyrpides, Nikos, Denton, Matt D, Howieson, John, Reeve, Wayne, Brau, Lambert, Nandesena, Kemanthi, Mavromatis, Konstantinos, Ivanova, Natalia, O\u27Hara, Graham William, Melino, Vanessa, Land, Miriam, Markowitz, Victor, Brettin, Thomas, Nolan, Matt, Ardley, Julie Kaye, Copeland, Alex +89 morecore +1 more sourceDifferential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 morewiley +1 more sourceQuality data of whole-genome-sequence and assembly.
, 2020 Quality data of whole-genome-sequence and assembly.Fumihiko Takeuchi (118220), Hisako Kyan (4922593), Akinori Yamano (8394009), Tatsunori Masatani (497109), Toshihiro Matsui (1917), Takaya Sakura (2016025), Mami Murakami (791941), Kisaburo Nagamune (180747), Ryuma Matsubara (813362), Junpei Fukumoto (8394006), Michiru Tahara (180743), Motomichi Matsuzaki (78878), Tomohide Matsuo (46062), Yasuhiro Takashima (188527) +13 morecore +1 more sourceA fragmented metazoan organellar genome [PDF]
, 2008 Background: Animal mitochondrial (mt) genomes are characteristically circular molecules of ~16–20 kb. Medusozoa (Cnidaria excluding Anthozoa) are exceptional in that their mt genomes are linear and sometimes subdivided into two to presumably four ...Wörheide, Gert, Erpenbeck, Dirk, Voigt, Oliver +2 morecore +1 more sourceSimple Sequence Repeat Marker Development and Mapping Targeted to Previously Unmapped Regions of the Strawberry Genome Sequence
The Plant Genome, 2011 The genome sequence of the woodland strawberry ( L.) is an important resource providing a reference for comparative genomics studies and future sequenced rosaceous species and has great utility as a model for the development of markers for mapping in the Daniel J. Sargent, Paulina Kuchta, Elena Lopez Girona, Hailong Zhang, Thomas M. Davis, Jean-Marc Celton, Annalisa Marchese, Malgorzata Korbin, Kevin M. Folta, Vladimir Shulaev, David W. Simpson +10 moredoaj +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceThe complexity of Rhipicephalus (Boophilus) microplus genome characterised through detailed analysis of two BAC clones [PDF]
, 2011 Background
Rhipicephalus (Boophilus) microplus (Rmi) a major cattle ectoparasite and tick borne disease vector, impacts on animal welfare and industry productivity.Peterson, D., Morgan Jess A T, Moolhuijzen, Paula M., Moolhuijzen, P.M., Dowd, S.E, Peterson, Daniel G., Bellgard, Matthew I., Bellgard Matthew I, Dowd Scot E, Bellgard, M.I., Appels, Rudi, Peterson Daniel G, Daniel G Peterson, Manuel Valle, Guerrero, F., Lew-Tabor, Ala E., Paula M Moolhuijzen, Valle, M.R., Appels Rudi, Moolhuijzen Paula M, Felix D Guerrero, Lew-Tabor, A.E., Lew-Tabor Ala E, Manuel Rodriguez Valle, Guerrero, F.D., Matthew I Bellgard, Lew-Tabor, A., Valle, Manuel Rodriguez, Guerrero Felix D, Moolhuijzen, Paula, Dowd, Scot E., Morgan, J.A.T., Dowd, S., Morgan, J., Valle, M., Bellgard, M., Scot E Dowd, Valle Manuel, Jess A T Morgan, Peterson, D.G., Appels, R., Rudi Appels, Ala E Lew-Tabor, Morgan, Jess A.T., Guerrero, Felix D., Department of Primary Industries, Queensland +45 morecore +2 more sources
