Results 181 to 190 of about 2,337,583 (311)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Ambient temperature storage of individual parasitic nematode larvae for whole genome sequencing. [PDF]

PLoS Negl Trop Dis
WORMS-SEA Consortium.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Comparison of Medium-Coverage Whole-Genome Sequencing and Chromosomal Microarray in Prenatal Testing of Absence of Heterozygosity. [PDF]

Prenat Diagn
Zhang M, Li J, Ren C, Liu Y, Bian W, Han X, Wang M, Chen X, Hu Y, Kan M, Liu L.   +10 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Exome and Genome Sequencing for the Diagnosis of Rare Diseases. [PDF]

Dtsch Arztebl Int
Elbracht M, Krause J, Mattern L, Güzel N, Lischka A, Sun-Julia Suh D, Knopp C, Bourgeois MG, Beijer D, D'Augello S, Haag N, Rüdebusch J, Perchalla E, Lausberg E, Eggermann K, Meyer R, Kraft F, Begemann M, Eggermann T, Kurth I, members of the study group.   +20 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Whole genome sequencing in cerebral palsy: a UK paediatric pilot study. [PDF]

Lancet Reg Health Eur
Ratnaike TE, Pierce HH, Coffey AJ, Dias JML, Kean IRL, Li E, More RP, Sumathipala DS, Bajracharya M, Kingsbury Z, Newington T, Rogers AS, Delon I, Downes K, de Alwis Y, Basu AP, Issa M, Kearney C, Khan AH, Marlow BP, Sansome A, Ahn J, Than AY, Lau T, Bentley DR, Bowdin S, Reid E, Houlden H, Humphray S, Rowitch DH.   +29 more
europepmc   +1 more source

Author Correction: The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities

Communications Biology
Eric Venner, Karynne Patterson, Divya Kalra, Marsha M. Wheeler, Yi-Ju Chen, Sara E. Kalla, Bo Yuan, Jason H. Karnes, Kimberly Walker, Joshua D. Smith, Sean McGee, Aparna Radhakrishnan, Andrew Haddad, Philip E. Empey, Qiaoyan Wang, Lee Lichtenstein, Diana Toledo, Gail Jarvik, Anjene Musick, Richard A. Gibbs, on behalf of the All of Us Research Program Investigators   +20 more
doaj   +1 more source