Results 191 to 200 of about 2,337,583 (311)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Identification of Novel Pathogenic Variants in Familial Adenomatous Polyposis Through Whole Genome Sequencing. [PDF]

Hum Mutat
Choi SR, Kim MJ, Ku JL, Jeong SY, Choi M, Park JW.   +5 more
europepmc   +1 more source

Initial sequencing and comparative analysis of the mouse genome

, 2002
CHIAROMONTE, FRANCESCA, International Mouse Genome Sequencing consortium including, Waterston R   +2 more
core  

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Citywide implementation of a rapid whole-genome sequencing program for critically ill pediatric patients. [PDF]

Nat Med
Rabea F, Aljasmi I, Jain R, Ramaswamy S, Taylor A, Shenbagam S, Chekroun I, Sinha S, El Naofal M, Yaslam S, Alfalasi R, Khadija S, Farag M, AlHajjaj S, Almadhoun F, Sharaf R, Khyriem C, Abulhoul H, Elabd H, Mustafa M, Almarri M, Du Plessis S, AlKhnbashi OS, Majid I, Buhumaid R, Al Suwaidi H, AlAwadhi M, AlKhayat A, Alsheikh-Ali A, Zahraa J, Shankar S, Abou Tayoun A.   +31 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Strategies for integrating whole-genome sequencing into antimicrobial resistance surveillance. [PDF]

BMC Genomics
On Y, Yoon EJ.
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting. [PDF]

PLoS One
Waggle KD, Griffith MP, Rokes AB, Rangachar Srinivasa V, Nawrocki EM, Ereifej D, Patrick R, Coyle H, Chaudhary S, Raabe NJ, Shutt K, Sundermann AJ, Cooper VS, Harrison LH, Pless LL.   +14 more
europepmc   +1 more source

Initial Sequencing and Analysis of the Human Genome

, 2001
International Human Genome Sequencing Consortium
core