Results 211 to 220 of about 2,337,583 (311)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Genome sequencing of fowl cholera vaccine strain <i>Pasteurella multocida</i> in Bangladesh. [PDF]

Microbiol Resour Announc
Mokta MB, Karim MR, Dey TR, Alam S, Mohiuddin ANMG, Hosain MZ, Kamal MM, Samad MA.   +7 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Ultra-low-pass whole-genome sequencing of bile cfDNA in patients with biliary strictures. [PDF]

eGastroenterology
Rojo C, Rullan M, Sogbe M, Herranz JM, Elizalde M, Oyón D, Vila JJ, Purroy A, Azkona M, Marchese FP, Krawczyk M, Fernández-Barrena MG, Sangro B, Argemi J, Urmán J, Ávila MA, Berasain C, Arechederra M.   +17 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Diagnosis Through Whole Genome Sequencing and Care Utilization in Children With Severe Illness.

JAMA Netw Open
Dias JML, More RP, Butler D, Brown J, French CE, Dolling H, Raymond FL, Rowitch DH, Aiken CE.   +8 more
europepmc   +1 more source

Genome Sequencing Enhances Precision and Clinical Utility of Pharmacogenetic Data Compared to Arrays. [PDF]

J Clin Pharmacol
Numanagić I, Similuk M, Sissung TM, Hari A, Ford MKB, Walkiewicz MA, Yan J, Ghosh R, Lack J, Cao W, Baugher RN, Young TB, Manolio T, Biesecker LG, Hewitt SM, Sahinalp SC, Holland SM, Figg WD.   +17 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The cold case of state transition 7 (stt7) mutants of Chlamydomonas reinhardtii, solved by whole-genome sequencing. [PDF]

New Phytol
Bujaldon S, Burlacot A, Chaux F, Wollman FA.   +3 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source