Results 121 to 130 of about 1,472,051 (229)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Evolution of Plant Genome Size and Composition. [PDF]

Genomics Proteomics Bioinformatics
He B, Liu W, Li J, Xiong S, Jia J, Lin Q, Liu H, Cui P.   +7 more
europepmc   +1 more source

Ecological factors and parity mode correlate with genome size variation in squamate reptiles. [PDF]

BMC Ecol Evol, 2023
Saha A, Bellucci A, Fratini S, Cannicci S, Ciofi C, Iannucci A.   +5 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Exploring the complexity of genome size reduction in angiosperms. [PDF]

Plant Mol Biol
Ezoe A, Seki M.
europepmc   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Correction: Genome size influences plant growth and biodiversity responses to nutrient fertilization in diverse grassland communities. [PDF]

PLoS Biol
Morton JA, Arnillas CA, Biedermann L, Borer ET, Brudvig LA, Buckley YM, Cadotte MW, Davies K, Donohue I, Ebeling A, Eisenhauer N, Estrada C, Haider S, Hautier Y, Jentsch A, Martinson H, McCulley RL, Raynaud X, Roscher C, Seabloom EW, Stevens CJ, Vesela K, Wallace A, Leitch IJ, Leitch AR, Hersch-Green EI.   +25 more
europepmc   +1 more source

Comparative genomics reveals insights into anuran genome size evolution. [PDF]

BMC Genomics, 2023
Zuo B, Nneji LM, Sun YB.
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Genome size estimation of false daisy, cheek weed, pot marigold and marigold. [PDF]

Bioinformation, 2023
Waquar AA, Ram K, Mohammad AA, Lee J.
europepmc   +1 more source