Results 81 to 90 of about 1,598,916 (291)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Complete genome sequence of Planctomyces limnophilus type strain (Mü 290). [PDF]

, 2010
Planctomyces limnophilus Hirsch and Müller 1986 belongs to the order Planctomycetales, which differs from other bacterial taxa by several distinctive features such as internal cell compartmentalization, multiplication by forming buds directly from the ...
Bristow, James, Chang, Yun-Juan, Chen, Amy, Cheng, Jan-Fang, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Labutti, Kurt, Land, Miriam, Lapidus, Alla, Liolios, Konstantinos, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Mikhailova, Natalia, Nolan, Matt, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Rohde, Manfred, Schneider, Susanne, Sikorski, Johannes, Tice, Hope, Tindall, Brian J, Woyke, Tanja   +31 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Complete genome sequence of the Medicago microsymbiont Ensifer (Sinorhizobium) medicae strain WSM419 [PDF]

, 2010
Ensifer (Sinorhizobium) medicae is an effective nitrogen fixing microsymbiont of a diverse range of annual Medicago (medic) species. Strain WSM419 is an aerobic, motile, non-spore forming, Gram-negative rod isolated from a M.
Ardley, J.K., Bräu, L., Chain, P., Chang, Y-J, Copeland, A., Dilworth, M.J., Gollagher, M., Hauser, L., Howieson, J.G., Ivanova, N., Kiss, H., Kyrpides, N, Land, M., Lapidus, A., Malfatti, S., Markowitz, V., Mavromatis, K., Nandasena, K.G., Nolan, M., O'Hara, G.W., Reeve, W.G., Tiwari, R., Yates, R.J.   +22 more
core   +1 more source

Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii [PDF]

, 2014
Estimates of mutational parameters, such as the average fitness effect of a new mutation and the rate at which new genetic variation for fitness is created by mutation, are important for the understanding of many biological processes. However, the causes
Adams, Baer, Baer, Baranyi, Barrick, Bateman, Charlesworth, Charlesworth, Crutchfield, Davies, Dickinson, Drake, Fernandez, Fisher, Fry, García-Dorado, Goffeau, Goho, Gong, Haerty, Halligan, Halligan, Hartfield, Joseph, Keightley, Keightley, Keightley, Keightley, Keightley, Keightley, Kibota, Knight, Kondrashov, Koonin, Liss, Loewe, Lukjancenko, Lynch, Lynch, Lynch, Lynch, Massey, Matic, Merchant, Mukai, Mukai, Ness, Otto, R Core Team, Schaack, Schoen, Schrider, Schultz, Sharp, Shaw, Smith, Sokal, Sousa, Sundin, Sung, The Arabadopsis, The C. elegans Sequencing Consortium, Torgerson, Winzeler, Zeyl, Zuur   +65 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Flow Cytometry Protocol for Measurement of Plant Genome Size Using Frozen Material

Applied Biosciences
Flow cytometry is widely applied to infer the ploidy and genome size (GS) of plant nuclei. The conventional approach of sample preparation, reliant on fresh plant material to release intact nuclei, often results in poor yields of nuclei in conditions ...
Abhishek Soni, Lena Constantin, Agnelo Furtado, Robert J Henry   +3 more
doaj   +1 more source

Genome Size and Species Diversification [PDF]

Evolutionary Biology, 2010
Theoretically, there are reasons to believe that large genome size should favour speciation. Several major factors contributing to genome size, such as duplications and transposable element activity have been proposed to facilitate the formation of new species. However, it is also possible that small genome size promotes speciation.
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Neutral Aggregation in Finite Length Genotype space

, 2016
The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness.
Houchmandzadeh, Bahram
core   +3 more sources