Results 91 to 100 of about 437,562 (315)

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex

EMBO Reports
Cyclosporin A (CsA) induces DNA double-strand breaks in LIG4 syndrome fibroblasts, specifically upon transit through S-phase. The basis underlying this has not been described.
Marisa Bedir, Emily Outwin, Rita Colnaghi, Lydia Bassett, Iga Abramowicz, Mark O’Driscoll   +5 more
doaj   +1 more source

ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

Frontiers in Cell and Developmental Biology, 2020
DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 ...
Winnie Tan, Winnie Tan, Sylvie van Twest, Vincent J. Murphy, Andrew J. Deans, Andrew J. Deans   +5 more
doaj   +1 more source

Whole Genome Incorporation and Epigenetic Stability in a Newly Synthetic Allopolyploid of Gynogenetic Gibel Carp

, 2018
Allopolyploidization plays an important role in speciation, and some natural or synthetic allopolyploid fishes have been extensively applied to aquaculture.
Wang, Yang, Shao, Guang-Ming, Li, Xi-Yin, Wang, Zhong-Wei, Zhou, Li, Li, Zhi, Gui, Jian-Fang, Zhang, Xiao-Juan   +7 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32

Nature Communications
Break-induced replication (BIR) facilitates single-ended DNA double-strand break (DSB) repair. Upon homologous recombination-mediated strand invasion into a homologous repair template, BIR is catalysed by a minimal replisome comprising PCNA, DNA ...
David Jones, Rowin Appanah, Luke A. Yates, Antony W. Oliver, Ulrich Rass   +4 more
doaj   +1 more source

Characterisation of a stably integrated expression system for exogenous protein expression in DT40 [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2017
The use of constitutive promoters to drive exogenous protein expression is an important tool for the study of diverse biological processes. To create and characterise a stably integrated expression system for DT40 cells, we constructed integration ...
Meliti Skouteri, Helfrid Hochegger, Antony M. Carr   +2 more
doaj   +1 more source

Aligning a new reference genetic map of lupinus angustifolius with the genome sequence of the model legume, Lotus japonicus

, 2009
We have developed a dense reference genetic map of Lupinus angustifolius (2n = 40) based on a set of 106 publicly available recombinant inbred lines derived from a cross between domesticated and wild parental lines.
Moolhuijzen, P.M., Swiecicki, W., K. Lesniewska, Cowling, W.A., Ellwood, Simon, Matthew N. Nelson, Paula M. Moolhuijzen, S. R. Ellwood, M. Chudy, Oliver, R.P., Simon R. Ellwood, Richard P. Oliver, Wallace A. Cowling, W. A. Cowling, Boersma, J.G., Ellwood, S.R., Magdalena Chudy, Matthew Bellgard, Oliver, Richard, B. Wolko, Chudy, M., Cowling, W., Boersma, J., Nelson, M., R. P. Oliver, J. G. Boersma, Lesniewska, K., Moolhuijzen, P., Bellgard, M., Nelson, M.N., Wolko, B., M. Bellgard, M. N. Nelson, Wolko, B.W., Karolina Lesniewska, Bogdan Wolko, P. M. Moolhuijzen, Jeffrey G. Boersma, W. Swiecicki   +38 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Power of Microbes in Industry and Environment 2023

, 2023
Genome stability is of paramount importance to all living organisms. Genome instability results in severe conditions such as cancer and premature aging in mammals, due to aberrant DNA rearrangements such as deletions, amplifications, translocations ...
Isidoro Feliciello
core