Results 111 to 120 of about 437,562 (315)

Aspergillus flavus NRRL 3357 wt AflW60-6 Resequencing genome sequencing

, 2016
Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core  

Maintenance of genome stability in Saccharomyces cerevisiae [PDF]

, 2002
Most human cancer cells show signs of genome instability, ranging from elevated mutation rates to gross chromosomal rearrangements and alter-ations in chromosome number. Little is known about the molecular mechanisms that generate this instability or how
Richard D. Kolodner, Christopher D. Putnam, Kyungjae Myung   +2 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Aspergillus flavus NRRL 3357 wt AflW60-10 Resequencing genome sequencing

, 2016
Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Aspergillus flavus NRRL 3357 wt AflW60-3 Resequencing genome sequencing

, 2016
Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core  

Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays. [PDF]

, 2010
Background: We report an attempt to extend the previously successful approach of combining SNP (single nucleotide polymorphism) microarrays and DNA pooling (SNP-MaP) employing high-density microarrays.
Farmer, A., Pirlo Katrina, Farmer, Anne E, Gray, J, Jones, L, Emma Meaburn (27672), Ian W Craig (16171385), Gaysina, D, Ian W Craig, Emma Meaburn, Craig, I., Korszun Ania, Cohen-Woods Sarah, Gray Joanna, Cohen-Woods, Sarah, Schalkwyk, L.C., McGuffin Peter, Darya Gaysina, Craig, Ian W, Farmer, AE, Schosser, A, Gray, J., Elkin, Amanda, Schalkwyk, L., Gray, Joanna, Craig, IW, Schalkwyk Leonard C, Schosser Alexandra, Lisa Jones (98953), Gunasinghe, C, Sarah Cohen-Woods (214940), Pirlo, K., Craig, I.W., Jones Lisa, Alexandra Schosser (214931), Gaysina Darya, Cerisse Gunasinghe (16171376), Schosser, Alexandra, McGuffin, P., Meaburn Emma, Meaburn, E., Amanda Elkin, Leonard C Schalkwyk, Alexandra Schosser, Ania Korszun (214946), Anne E Farmer, Joanna Gray, Lisa Jones, McGuffin, P, Pirlo, Katrina, Elkin Amanda, Katrina Pirlo, Gaysina, Darya, Schosser, A., Elkin, A., Schalkwyk, LC, Korszun, A., Peter McGuffin, Gunasinghe, Cerisse, Amanda Elkin (16049114), Craig Ian W, Sarah Cohen-Woods, Joanna Gray (16171373), Anne E Farmer (10497512), Farmer Anne E, Gaysina, Daria, Ania Korszun, Pirlo, K, Gunasinghe, C., Peter McGuffin (51507), Meaburn, Emma L., Elkin, A, Katrina Pirlo (14918094), Gaysina, D., Cerisse Gunasinghe, Korszun, A, Farmer, A.E., McGuffin, Peter, Korszun, Ania, Jones, Lisa, Leonard C Schalkwyk (8412954), Cohen-Woods, S, McGuffin, Peter W, Meaburn, E, Darya Gaysina (4464832), Schalkwyk, Leonard C, Cohen-Woods, S., Gunasinghe Cerisse, Jones, L., Gunasinghe, Cerisse; id_orcid, Meaburn, Emma   +90 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Genome stability

Seminars in Cell & Developmental Biology, 2021
openaire   +3 more sources

HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients

Cell Reports, 2017
Summary: Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases.
Zhaobo Li, Lihong Zhou, Chrisostomos Prodromou, Velibor Savic, Laurence H. Pearl   +4 more
doaj   +1 more source