Results 131 to 140 of about 437,562 (315)
Aspergillus flavus NRRL 3357 wt AflW60-9 Resequencing genome sequencing
, 2016 Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core
, 2005 Brune I, Brinkrolf K, Kalinowski J, Pühler A, Tauch A. The individual and common repertoire of DNA-binding transcriptional regulators of Corynebacterium glutamicum, Corynebacterium efficiens, Corynebacterium diphtheriae and Corynebacterium jeikeium ...
Brune, Iris +4 more
core +1 more source
Genome hyperevolution and the success of a parasite [PDF]
, 2012 The strategy of antigenic variation is to present a constantly changing population phenotype that enhances parasite transmission, through evasion of immunity arising within, or existing between, host animals.
J. David Barry +5 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Organization, stability, and expression of the genome
Molecular Biology of the Cell, 2014 At this year's ASCB meeting, the dynamic genome took center stage. Three Minisymposia carried this thread from start to finish, revealing the impacts of cell biology on all aspects of the genome. New concepts about the physical nature and organization of chromatin were presented, highlighting cutting-edge techniques such as high-throughput chromosome ...
openaire +2 more sources
Aspergillus flavus NRRL 3357 wt AflW60-7 Resequencing genome sequencing
, 2016 Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Super DNAging - New insights into DNA integrity, genome stability and telomeres in the oldest old
, 2015 Reductions in DNA integrity, genome stability, and telomere length are strongly associated with the aging process, age-related diseases as well as the age-related loss of muscle mass.
Franzke, Bernhard +2 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source