Results 121 to 130 of about 437,562 (315)

Correction: FTSJ1 regulates tRNA 2ʹ-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression

Cell Death and Disease, 2020
The original version of this article contained an error in the spelling of the author Yuchen Chen, which was incorrectly given as Yuhuan Chen. This has now been corrected in both the PDF and HTML versions of the article.
Qihan He, Lin Yang, Kaiping Gao, Peikun Ding, Qianqian Chen, Juan Xiong, Wenhan Yang, Yi Song, Liang Wang, Yejun Wang, Lijuan Ling, Weiming Wu, Jisong Yan, Peng Zou, Yuhuan Chen, Rihong Zhai   +15 more
doaj   +1 more source

Epigenetic mechanisms and genome stability

Clinical Epigenetics, 2010
Abstract Epigenetic marks are well recognized as heritable chemical modifications of DNA and chromatin that induce chromatin structural changes thereby affecting gene activity. A lesser-known phenomenon is the pervasive effects these marks have on genomic integrity. Remarkably, epigenetic marks and the enzymes that establish them are involved
Putiri, Emily L., Robertson, Keith D.
openaire   +3 more sources

Aspergillus flavus NRRL 3357 wt AflW60-8 Resequencing genome sequencing

, 2016
Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core  

Centrosomes are multifunctional regulators of genome stability

, 2016
The maintenance of genome stability is critical for proper cell function, and loss of this stability contributes to many human diseases and developmental disorders.
Poulton, John S., Lerit, Dorothy A.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Aspergillus flavus NRRL 3357 wt AflW60-5 Resequencing genome sequencing

, 2016
Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Aspergillus flavus NRRL 3357 wt AflW60-4 Resequencing genome sequencing

, 2016
Genome sequencing of Aspergillus flavus strain to assess the consequences of the elimination of the NHEJ DNA repair mechanisms on the genome stability and fungal ...
DOE Joint Genome Institute (17854997)
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism

BMC Complementary and Alternative Medicine, 2018
Background Homoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood. Methods We examined the effect of HHT on alternative splicing of Bcl-x and Caspase 9 in various cells
Qi Sun, Shiyue Li, Junjun Li, Qiuxia Fu, Zhongyuan Wang, Bo Li, Shan-Shan Liu, Zijie Su, Jiaxing Song, Desheng Lu   +9 more
doaj   +1 more source