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RAD51, genomic stability, and tumorigenesis
Cancer Letters, 2005Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to ...
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Vitamin C and genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001Vitamin C, a water-soluble glucose derivative, has considerable antioxidant activity in vitro, in part because of its ease of oxidation and because the semidehydroascorbate radical derived from it is of low reactivity. Vitamin C in vivo is an essential cofactor for a range of enzymes involved in diverse metabolic pathways, but much recent literature ...
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Role of magnesium in genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001In cellular systems, magnesium is the second most abundant element and is involved in basically all metabolic pathways. At physiologically relevant concentrations, magnesium itself is not genotoxic, but is highly required to maintain genomic stability. Besides its stabilizing effect on DNA and chromatin structure, magnesium is an essential cofactor in ...
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2016
Ageing is defined as the progressive attrition of tissue/organ function resulting in an increased susceptibility to disease and death. The DNA mutation and damage theory of ageing posits that the accrual of genetic damage over time is the underlying cause of ageing.
Aditi U. Gurkar +2 more
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Ageing is defined as the progressive attrition of tissue/organ function resulting in an increased susceptibility to disease and death. The DNA mutation and damage theory of ageing posits that the accrual of genetic damage over time is the underlying cause of ageing.
Aditi U. Gurkar +2 more
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The Ubiquitin Proteasome System in Genome Stability and Cancer
Cancers, 2021Jonathan J Morgan, Lisa J Crawford
exaly
E2 enzymes in genome stability: pulling the strings behind the scenes
Trends in Cell Biology, 2021Josep V Forment +1 more
exaly
Maintaining the Stability of the Genome
1996Ageing may be defined as the time-dependent general decline of physiological functions of an organism, which is associated with a progressively rising risk of morbidity and mortality. For many different types of cancer, for instance, old age is a very important, if not the single most important risk factor1.
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[BRCA1 and genomic stability].
Ai zheng = Aizheng = Chinese journal of cancer, 2003BRCA1 is a 220kDa nuclear protein with multiple functional domains. It interacts directly or indirectly with a variety of important proteins, including oncogene proteins (c-myc, E2F), tumor suppressor proteins (p53, RB, BRCA2), DNA damage repair proteins (RAD50, RAD51), cell-cycle regulators (cyclin, CDK), transcriptional regulators (RNA polymerase II)
Wen-Hong, Fan, Qi-Min, Zhan
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