Results 311 to 320 of about 733,963 (352)

Iron and genome stability: An update

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012
Iron is an essential micronutrient which is required in a relatively narrow range for maintaining metabolic homeostasis and genome stability. Iron participates in oxygen transport and mitochondrial respiration as well as in antioxidant and nucleic acid metabolism.
Daniel, Prá, Silvia Isabel Rech, Franke, João Antonio Pêgas, Henriques, Michael, Fenech   +3 more
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Vitamin E and genome stability

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
Free radicals and reactive oxygen species (ROS) which are generated continuously cause mutagenic alterations resulting in cancer, aging and abnormalities in the nervous system. Accumulating evidence indicates that Vitamin E, the most potent lipid peroxyl radical scavenger, may reduce free radical induced chromosomal damages through inhibition of free ...
K J, Claycombe, S N, Meydani
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Chromosome segregation and genomic stability

Current Opinion in Genetics & Development, 2004
The acquisition of genomic instability is a crucial step in the development of human cancer. Genomic instability has multiple causes of which chromosomal instability (CIN) and microsatellite instability (MIN) have received the most attention. Whereas the connection between a MIN phenotype and cancer is now proven, the argument that CIN causes cancer ...
Viji M, Draviam, Stephanie, Xie, Peter K, Sorger   +2 more
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The role of zinc in genomic stability

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012
Zinc (Zn) is an essential trace element required for maintaining both optimal human health and genomic stability. Zn plays a critical role in the regulation of DNA repair mechanisms, cell proliferation, differentiation and apoptosis involving the action of various transcriptional factors and DNA or RNA polymerases.
Sharif, R., Thomas, P., Zalewski, P., Fenech, M.   +3 more
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Genomic stability of gibbon oncornavirus

Journal of Virology, 1978
The 70S RNAs from several gibbon type C viruses were examined for sequence homology by molecular hybridization using complementary DNA probes. The sequence homology was found to vary with each virus isolate. The genome from one isolate was examined for genomic stability after the virus was experimentally passaged through three unrelated gibbons.
L, Sun, T G, Kawakami, S I, Matoba
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Diet and Genomic Stability

2007
Cancer results from a disordered and unstable genome - the degree of abnormality progresses as the process of oncogenesis proceeds. Such genomic instability appears to be subject to control by environmental factors as evidenced by the number of cancers that are either caused by specific environmental agents (lung, skin, cervix) or else regulated by a ...
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Function of TopBP1 in Genome Stability

2009
Human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and its orthologues in other organisms are proteins consisting of multiple BRCT modules that have acquired several functions during evolution. These proteins execute their tasks by interacting with a great variety of proteins involved in nuclear processes. TopBP1 is an essential protein that has
Miiko, Sokka, Sinikka, Parkkinen, Helmut, Pospiech, Juhani E, Syväoja   +3 more
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Telomere dynamics in genome stability

Trends in Biochemical Sciences, 2006
The past several years have seen an increasing interest in telomere recombinational interactions that provide many functions in telomere capping, in telomere size homeostasis and in overcoming the catastrophic effects of telomerase deficiency. Several key recombination mechanisms have emerged from recent investigations.
Mrinal K, Bhattacharyya, Arthur J, Lustig   +1 more
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Vitamin D and genomic stability

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] has been shown to act on novel target tissues not related to calcium homeostasis. There have been reports characterizing 1,25(OH)(2)D(3) receptors and activities in diverse tissues such as brain, pancreas, pituitary, skin, muscle, placenta, immune cells and parathyroid.
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Copper and genomic stability in mammals

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
As the free ion and in the form of some complexes, there is no doubt that copper can promote damage to cellular molecules and structures through radical formation. At the same time, and perhaps as a consequence, mammals have evolved means of minimizing levels of free copper ions and destructive copper complexes that enter the organism and its cells ...
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