Results 291 to 300 of about 733,963 (352)

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Condensin II interacts with BLM helicase in S phase to maintain genome stability. [PDF]

Commun Biol
Rodemoyer B, Kariyawasam G, Subramanian V, Schmidt K.   +3 more
europepmc   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division. [PDF]

J Cell Biol
Hwang S, Russo W, Cormier J, Johnson J, Martin S, Ippolito MR, Cordone S, Li R, Zhu LJ, Santaguida S, Torres EM.   +10 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

The Role of Fanconi Anemia Proteins in DNA Repair, Replication Stress and Genome Stability

, 2017
Elizabeth L. Thompson
openalex   +1 more source

Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas. [PDF]

Int J Mol Sci
Cruz P, Peña-Lopez D, Figueroa D, Riobó I, Benedetti V, Saavedra F, Espinoza-Arratia C, Escobar TM, Lladser A, Loyola A.   +9 more
europepmc   +1 more source

Histone H3 mutations and their impact on genome stability maintenance. [PDF]

Biochem Soc Trans
Caeiro LD, Verdun RE, Morey L.
europepmc   +1 more source

Pyrimidine and NAD salvage pathways : unexpected allies in the maintenance of genome stability

, 2018
Sandra Cunha Silveira
openalex   +1 more source