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DEAD-Box RNA Helicases and Genome Stability
Genes, 2021 DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome ...
Rasika Venkataraman
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Epigenetics and genome stability
Mammalian Genome, 2020Maintaining genome stability is essential to an organism's health and survival. Breakdown of the mechanisms protecting the genome and the resulting genome instability are an important aspect of the aging process and have been linked to diseases such as cancer. Thus, a large network of interconnected pathways is responsible for ensuring genome integrity
Justina X. Feng, Nicole C. Riddle
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Genomic stability in reprogramming
Current Opinion in Genetics & Development, 2012The genetic stability of induced pluripotent stem (iPS) cells has a significant impact on their potential use in regenerative medicine and basic research. Analysis of the genomic integrity of iPS cells suggests a tendency to develop aberrations ranging from whole chromosome trisomies to single nucleotide mutations. Furthermore, fluctuations in telomere
Daniel, Ronen, Nissim, Benvenisty
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Genome (in)stability at tandem repeats
Seminars in Cell & Developmental Biology, 2021Repeat sequences account for over half of the human genome and represent a significant source of variation that underlies physiological and pathological states. Yet, their study has been hindered due to limitations in short-reads sequencing technology and difficulties in assembly.
Elisa Balzano +2 more
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Carotenoids and genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001Epidemiological evidence abounds for a link between intake of carotenoids from fruit and vegetable foods and relatively low incidence of various cancers. However, intervention trials have shown, in some cases, a significant increase in occurrence of lung cancer in those volunteers taking supplements of beta-carotene.
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Iron and genome stability: An update
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012Iron is an essential micronutrient which is required in a relatively narrow range for maintaining metabolic homeostasis and genome stability. Iron participates in oxygen transport and mitochondrial respiration as well as in antioxidant and nucleic acid metabolism.
Daniel, Prá +3 more
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Vitamin E and genome stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001Free radicals and reactive oxygen species (ROS) which are generated continuously cause mutagenic alterations resulting in cancer, aging and abnormalities in the nervous system. Accumulating evidence indicates that Vitamin E, the most potent lipid peroxyl radical scavenger, may reduce free radical induced chromosomal damages through inhibition of free ...
K J, Claycombe, S N, Meydani
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Chromosome segregation and genomic stability
Current Opinion in Genetics & Development, 2004The acquisition of genomic instability is a crucial step in the development of human cancer. Genomic instability has multiple causes of which chromosomal instability (CIN) and microsatellite instability (MIN) have received the most attention. Whereas the connection between a MIN phenotype and cancer is now proven, the argument that CIN causes cancer ...
Viji M, Draviam +2 more
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The role of zinc in genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012Zinc (Zn) is an essential trace element required for maintaining both optimal human health and genomic stability. Zn plays a critical role in the regulation of DNA repair mechanisms, cell proliferation, differentiation and apoptosis involving the action of various transcriptional factors and DNA or RNA polymerases.
Sharif, R. +3 more
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Genomic stability of gibbon oncornavirus
Journal of Virology, 1978The 70S RNAs from several gibbon type C viruses were examined for sequence homology by molecular hybridization using complementary DNA probes. The sequence homology was found to vary with each virus isolate. The genome from one isolate was examined for genomic stability after the virus was experimentally passaged through three unrelated gibbons.
L, Sun, T G, Kawakami, S I, Matoba
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