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Function of TopBP1 in Genome Stability
2009Human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and its orthologues in other organisms are proteins consisting of multiple BRCT modules that have acquired several functions during evolution. These proteins execute their tasks by interacting with a great variety of proteins involved in nuclear processes. TopBP1 is an essential protein that has
Miiko, Sokka +3 more
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2007
Cancer results from a disordered and unstable genome - the degree of abnormality progresses as the process of oncogenesis proceeds. Such genomic instability appears to be subject to control by environmental factors as evidenced by the number of cancers that are either caused by specific environmental agents (lung, skin, cervix) or else regulated by a ...
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Cancer results from a disordered and unstable genome - the degree of abnormality progresses as the process of oncogenesis proceeds. Such genomic instability appears to be subject to control by environmental factors as evidenced by the number of cancers that are either caused by specific environmental agents (lung, skin, cervix) or else regulated by a ...
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Vitamin D and genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 20011alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] has been shown to act on novel target tissues not related to calcium homeostasis. There have been reports characterizing 1,25(OH)(2)D(3) receptors and activities in diverse tissues such as brain, pancreas, pituitary, skin, muscle, placenta, immune cells and parathyroid.
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Telomere dynamics in genome stability
Trends in Biochemical Sciences, 2006The past several years have seen an increasing interest in telomere recombinational interactions that provide many functions in telomere capping, in telomere size homeostasis and in overcoming the catastrophic effects of telomerase deficiency. Several key recombination mechanisms have emerged from recent investigations.
Mrinal K, Bhattacharyya +1 more
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Copper and genomic stability in mammals
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001As the free ion and in the form of some complexes, there is no doubt that copper can promote damage to cellular molecules and structures through radical formation. At the same time, and perhaps as a consequence, mammals have evolved means of minimizing levels of free copper ions and destructive copper complexes that enter the organism and its cells ...
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RAD51, genomic stability, and tumorigenesis
Cancer Letters, 2005Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to ...
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Vitamin C and genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001Vitamin C, a water-soluble glucose derivative, has considerable antioxidant activity in vitro, in part because of its ease of oxidation and because the semidehydroascorbate radical derived from it is of low reactivity. Vitamin C in vivo is an essential cofactor for a range of enzymes involved in diverse metabolic pathways, but much recent literature ...
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Role of magnesium in genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001In cellular systems, magnesium is the second most abundant element and is involved in basically all metabolic pathways. At physiologically relevant concentrations, magnesium itself is not genotoxic, but is highly required to maintain genomic stability. Besides its stabilizing effect on DNA and chromatin structure, magnesium is an essential cofactor in ...
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2016
Ageing is defined as the progressive attrition of tissue/organ function resulting in an increased susceptibility to disease and death. The DNA mutation and damage theory of ageing posits that the accrual of genetic damage over time is the underlying cause of ageing.
Aditi U. Gurkar +2 more
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Ageing is defined as the progressive attrition of tissue/organ function resulting in an increased susceptibility to disease and death. The DNA mutation and damage theory of ageing posits that the accrual of genetic damage over time is the underlying cause of ageing.
Aditi U. Gurkar +2 more
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The Ubiquitin Proteasome System in Genome Stability and Cancer
Cancers, 2021Jonathan J Morgan, Lisa J Crawford
exaly