Results 131 to 140 of about 839,242 (267)

Plastid genome structure and phylogenomics of the freshwater red algal order Batrachospermales (Rhodophyta). [PDF]

J Phycol
Crowell RM, Lemes Da Silva NM, Paiano MO, Vis ML, Necchi O.   +4 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

A genome-structure adaptive framework for ROH-based inbreeding estimation in Penaeus vannamei. [PDF]

Sci Rep
Zou X, Zhou H, Liu M, Qiang G, Dai P, Sui J, Kong J, Luo K, Meng X, Xing Q, Fu Q, Luan S.   +11 more
europepmc   +1 more source

Three-dimensional genome structure and function. [PDF]

MedComm (2020), 2023
Liu H, Tsai H, Yang M, Li G, Bian Q, Ding G, Wu D, Dai J.   +7 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Conservation of bilaterian genome structure is the exception, not the rule. [PDF]

Genome Biol
Lewin TD, Liao IJ, Luo YJ.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Pervasive genome structure heterogeneity in <i>Mycobacterium tuberculosis</i> constitutively generates subpopulations with distinct clinical phenotypes. [PDF]

iScience
Modlin SJ, Robinhold C, Elghraoui A, Valafar F.   +3 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The complete mitochondrial genome of Sindiplozoon coreius: genome structure description, comparative analysis, and phylogenetic implications. [PDF]

BMC Genomics
Shen L, Fan LX, Meng FY.
europepmc   +1 more source