Results 201 to 210 of about 1,458,308 (328)

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source

Transcriptional machinery as an architect of genome structure. [PDF]

Curr Opin Struct Biol
Fursova NA, Larson DR.
europepmc   +1 more source

A Genome Wide Survey of SNP Variation Reveals the Genetic Structure of Sheep Breeds

, 2009
James Kijas, David Townley, Brian P. Dalrymple, Michael P. Heaton, J F Maddox, Annette McGrath, Peter Wilson, Roxann Ingersoll, Russell McCulloch, Sean McWilliam, Dave Tang, John C. McEwan, Noelle Cockett, V. H. Oddy, F. W. Nicholas, Herman W. Raadsma   +15 more
openalex   +2 more sources

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Genome structure and molecular phylogeny of the only Eurasian Boechera species, Boechera falcata (Brassicaceae). [PDF]

G3 (Bethesda)
Zilov D, Mandáková T, Popova M, Lysak MA, Windham MD, Brukhin V.   +5 more
europepmc   +1 more source

Structured RNAs in the ENCODE selected regions of the human genome [PDF]

, 2007
Stefan Washietl, Jakob Skou Pedersen, Jan O. Korbel, Claudia Stocsits, Andreas Gruber, Jörg Hackermüller, Jana Hertel, Manja Lindemeyer, Kristin Reiche, Andrea Tanzer, Catherine Ucla, Carine Wyss, Stylianos E. Antonarakis, France Denœud, Julien Lagarde, Jörg Drenkow, Philipp Kapranov, T Gingeras, Roderic Guigó, M Snyder, Mark Gerstein, Alexandre Reymond, Ivo L. Hofacker, Peter F. Stadler   +23 more
openalex   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Laboratory evolution of the bacterial genome structure through insertion sequence activation. [PDF]

Nucleic Acids Res
Kanai Y, Shibai A, Yokoi N, Tsuru S, Furusawa C.   +4 more
europepmc   +1 more source

Complete mitochondrial genome and phylogenetic analysis of Orbilia dorsalia, a species producing mature sexual structures on culture [PDF]

, 2019
Shaojuan Wang, Mei-Ling Fang, Jianping Xu, Lili Jiang, Duanyong Zhou, Ke‐Qin Zhang, Ying Zhang   +6 more
openalex   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source