Results 301 to 310 of about 1,458,308 (328)
A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons
Szabó D +17 more
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Advances in structural genomics
Current Opinion in Structural Biology, 1999New computational techniques have allowed protein folds to be assigned to all or parts of between a quarter (Caenorhabditis elegans) and a half (Mycoplasma genitalium) of the individual protein sequences in different genomes. These assignments give a new perspective on domain structures, gene duplications, protein families and protein folds in genome ...
S A, Teichmann, C, Chothia, M, Gerstein
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Structural Genomics and Genome Sequencing [PDF]
, 2010 Sugarcane exemplifies many challenges associated with genetic and genomic analysis of angiosperme, being a recently formed autopolyploid with a large genome, and with its most economically important forms being aneuploid interspecific hybrids. Despite nearly two decades of vigorous activity, current genetic maps remain "incomplete" (with some ...
Paterson, Andrew H. +4 more
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Genome structure of spirochetes
Research in Microbiology, 1992The genome structures of several pathogenic spirochetes have recently been determined. The genomes of Borrelia species consist of a linear chromosome of approximately one million base pairs (Mb) and various linear and circular plasmids. Analysis of restriction fragment length polymorphisms and 16S ribosomal RNA sequence data indicate the division of ...
I, Saint Girons +5 more
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Structural genomics in endocrinology
Pharmacogenomics, 2001Traditionally, endocrine research evolved from the phenotypical characterisation of endocrine disorders to the identification of underlying molecular pathophysiology. This approach has been, and still is, extremely successful. The introduction of genomics and proteomics has resulted in a reversal of this sequence of endocrine research: reverse ...
Smit, J. W., Romijn, J. A.
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Trends in Biotechnology, 2005
G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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Nature Reviews Genetics, 2001
Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models
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Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models
openaire +2 more sources