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Structural genomics in endocrinology
Pharmacogenomics, 2001Traditionally, endocrine research evolved from the phenotypical characterisation of endocrine disorders to the identification of underlying molecular pathophysiology. This approach has been, and still is, extremely successful. The introduction of genomics and proteomics has resulted in a reversal of this sequence of endocrine research: reverse ...
Smit, J. W., Romijn, J. A.
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Genome structure of spirochetes
Research in Microbiology, 1992The genome structures of several pathogenic spirochetes have recently been determined. The genomes of Borrelia species consist of a linear chromosome of approximately one million base pairs (Mb) and various linear and circular plasmids. Analysis of restriction fragment length polymorphisms and 16S ribosomal RNA sequence data indicate the division of ...
I, Saint Girons +5 more
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Trends in Biotechnology, 2005
G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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Genome Structure and Comparative Genomics
2016Two genome assemblies have been generated for Setaria italica, one in the accession Yugu1 and one in the accession Zhang gu. A comparison of the two assemblies showed overall high levels of colinearity, but identified a number of likely misoriented and/or misplaced sequence scaffolds.
Katrien M. Devos, Xiaomei Wu, Peng Qi
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Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2002
T, Nakayama, S, Yokoyama
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T, Nakayama, S, Yokoyama
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