Results 21 to 30 of about 188,588 (300)

Microbial genome-wide association studies: lessons from human GWAS [PDF]

Nature Reviews Genetics, 2016
AbstractThe reduced costs of sequencing have led to the availability of whole genome sequences for a large number of microorganisms, enabling the application of microbial genome wide association studies (GWAS). Given the successes of human GWAS in understanding disease aetiology and identifying potential drug targets, microbial GWAS is likely to ...
Power, Robert A., Parkhill, Julian, de Oliveira, Tulio   +2 more
openaire   +2 more sources

A Genome-Wide Association Study (GWAS) for Bronchopulmonary Dysplasia [PDF]

Pediatrics, 2013
OBJECTIVE: Twin studies suggest that heritability of moderate-severe bronchopulmonary dysplasia (BPD) is 53% to 79%, we conducted a genome-wide association study (GWAS) to identify genetic variants associated with the risk for BPD.
Wang, Hui, St. Julien, Krystal R, Stevenson, David K, Hoffmann, Thomas J, Witte, John S, Lazzeroni, Laura C, Krasnow, Mark A, Quaintance, Cecele C, Oehlert, John W, Jelliffe-Pawlowski, Laura L, Gould, Jeffrey B, Shaw, Gary M, O’Brodovich, Hugh M   +12 more
openaire   +5 more sources

Genetic Predisposition to Neuroblastoma

Children, 2018
Neuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis.
Erin K. Barr, Mark A. Applebaum
doaj   +1 more source

Genome-wide association studies in Plasmodium species [PDF]

, 2010
Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be ...
Bridget Penman, Caroline Buckee, Sean Nee, Sunetra Gupta   +3 more
core   +3 more sources

Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]

, 2019
BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas, Jhamb, Deepali, Rajpal, Deepak K, Shu, Le, Yang, Xia, Zhao, Yuqi   +5 more
core   +3 more sources

Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders [PDF]

, 2017
Bipolar disorder (BPD) and major depressive disorder (MDD) are primary major mood disorders. Recent studies suggest that they share certain psychopathological features and common risk genes, but unraveling the full genetic architecture underlying the ...
Amin, Najaf, Castelao, Enrique, Chang, Hong, Cichon, Sven, Consortium, MooDS Bipolar, Dis, Adv Collaborative Study Mood, Fang, Yiru, Forstner, Andreas J, Grigoroiu-Serbanescu, Maria, Hecker, Julian, Ikeda, Masashi, Iwata, Nakao, Kamatani, Yoichiro, Kubo, Michiaki, Kutalik, Zoltan, Li, Lingyi, Li, Ming, Luo, Xiong-Jian, Martin, Nicholas G, Mitchell, Philip B, Mueller-Myhsok, Bertram, Noethen, Markus M, Pistis, Giorgio, Preisig, Martin, Reif, Andreas, Rietschel, Marcella, Schofield, Peter R, Schulze, Thomas G, Strohmaier, Jana, Takahashi, Atsushi, van Duijn, Cornelia M, Wang, Chuang, Wang, Lu, Xiao, Xiao, Yao, Yong-Gang, Yuan, Ti-Fei, Zhang, Chen, Zheng, Fanfan, Zhou, Dongsheng   +38 more
core   +8 more sources

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation [PDF]

, 2016
We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations within the major histocompatibility complex (MHC) region, 15 non-MHC loci ...
Andlauer, TF, Antony, G, Arloth, J, Bayas, A, Bechmann, L, Berger, K, Berthele, A, Bertram, L, Bettecken, T, Binder, EB, Buck, D, Carrillo-Roa, T, Chan, A, Cucca, F, Czamara, D, Dankowski, T, Franke, A, Gasperi, C, Gieger, C, Gold, R, Graetz, C, Haas, J, Hecker, M, Hemmer, B, Herms, S, Homuth, G, Infante-Duarte, C, Ising, M, Jöckel, KH, Kacprowski, T, Kloiber, S, Knop, M, Kümpfel, T, Laudes, M, Lichtner, P, Lieb, W, Lill, CM, Limmroth, V, Linker, RA, Loleit, V, Lucae, S, Luessi, F, Meitinger, T, Meuth, SG, Moebus, S, Mulas, A, Mühlau, M, Müller-Myhsok, B, Müller-Nurasyid, M, Nischwitz, S, Nöthen, MM, Paul, F, Petersmann, A, Pitzalis, M, Porcu, E, Pütz, M, Radivojkov-Blagojevic, M, Rawal, R, Ruck, T, Salmen, A, Scheinhardt, MO, Schminke, U, Sidore, C, Stangel, M, Stellmann, JP, Strauch, K, Stürner, KH, Tackenberg, B, Then Bergh, F, Tumani, H, Völzke, H, Waldenberger, M, Warnke, C, Weber, F, Weber, P, Wellmann, J, Wiendl, H, Wildemann, B, Zara, I, Zettl, UK, Ziegler, A, Ziemann, U, Zipp, F, Zoledziewska, M   +83 more
core   +2 more sources

Genetic susceptibility to feline infectious peritonitis in Birman cats. [PDF]

, 2013
Genetic factors are presumed to influence the incidence of feline infectious peritonitis (FIP), especially among pedigreed cats. However, proof for the existence of such factors has been limited and mainly anecdotal.
Golovko, Lyudmila, Liu, Hongwei, Lyons, Leslie A, Pedersen, Niels C, Sørensen, Anne, Wehnert, Suzanne   +5 more
core   +1 more source

Genome-wide association study comparison analysis based on Hanwoo full-sib family [PDF]

Animal Bioscience
Objective The improvement of carcass traits is essential for the Hanwoo industry because of the Hanwoo grade determination system, and genome-wide association study (GWAS) analysis is an instrumental tool for identifying the genetic factors that impact ...
Ji-Yeong Kim, Eun-Ho Kim, Ho-Chan Kang, Cheol-Hyun Myung, Il-Keun Kong, Hyun-Tae Lim   +5 more
doaj   +1 more source

Identification of hub genes regulating isoflavone accumulation in soybean seeds via GWAS and WGCNA approaches

Frontiers in Plant Science, 2023
IntroductionIsoflavones are the secondary metabolites synthesized by the phenylpropanoid biosynthesis pathway in soybean that benefits human and plant health.MethodsIn this study, we have profiled seed isoflavone content by HPLC in 1551 soybean ...
Muhammad Azam, Shengrui Zhang, Jing Li, Muhammad Ahsan, Kwadwo Gyapong Agyenim-Boateng, Jie Qi, Yue Feng, Yitian Liu, Bin Li, Lijuan Qiu, Junming Sun   +10 more
doaj   +1 more source