Results 61 to 70 of about 188,588 (300)

Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students [PDF]

, 2017
Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms ...
Adkins, Amy, Aliev, Fazil, Cho, Seung B., Cooke, Megan E., Dick, Danielle M., Edwards, Alexis C., Kendler, Kenneth S., Kitchens, James N., Neale, Zoe, Pedersen, Kimberly, Riley, Brien P., Salvatore, Jessica E., Savage, Jeanne E., Sun, Cuie, Webb, Bradley T., Williamson, Vernell S., Wolen, Aaron R.   +16 more
core   +2 more sources

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies

Arthritis Research & Therapy, 2019
Background Chondropathies are a group of cartilage diseases, which share some common pathogenetic features. The etiology of chondropathies is still largely obscure now.
Ping Li, Yujie Ning, Xiong Guo, Yan Wen, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Sen Wang, Feng Zhang   +9 more
doaj   +1 more source

Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets

BMC Medical Genomics, 2023
Objectives Epidemiological studies have confirmed that low birth weight (BW) is related to neuroticism and they may have a common genetic mechanism based on phenotypic correlation research.
Xiao-Ying Zhou, Rui-Ke Liu, Chun-Ping Zeng   +2 more
doaj   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Genome-Wide Association Studies of Maize Seedling Root Traits under Different Nitrogen Levels

Plants, 2022
Nitrogen (N) is one of the important factors affecting maize root morphological construction and growth development. An association panel of 124 maize inbred lines was evaluated for root and shoot growth at seedling stage under normal N (CK) and low N ...
Yafang Fu, Jianchao Liu, Zhenqing Xia, Qi Wang, Shibo Zhang, Guixin Zhang, Haidong Lu   +6 more
doaj   +1 more source

Nonsyndromic cleft palate:An association study at GWAS candidate loci in a multiethnic sample [PDF]

, 2018
Background: Nonsyndromic cleft palate only (nsCPO) is a common and multifactorial form of orofacial clefting. In contrast to successes achieved for the other common form of orofacial clefting, that is, nonsyndromic cleft lip with/without cleft palate ...
Aldhorae, Beaty, Beaty, Beaty, Becker, Bhattacherjee, Birnbaum, Cobat, Ding, Exome Aggregation Consortium, Grosen, Hennekam, Hoebel, Johnson, Kheradpour, Leslie, Leslie, Leslie, Li, Ludwig, Ludwig, Ludwig, Ludwig, Mangold, Mangold, Mangold, McCarthy, Moreno, Moreno-Uribe, Mossey, Mostowska, Rahimov, Sun, The 1000 genomes Project Consortium, Thieme, Wang, Willer, Yu   +37 more
core   +2 more sources

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer

Journal of Immunology Research, 2022
Background. Colorectal cancer (CRC) is among the most common cancers diagnosed worldwide. Although genome-wide association studies have effectively identified the genetic basis of CRC, there is still unexplained variability in genetic risk. Transcriptome-
Ruimin Yin, Binbin Song, Jingjing Wang, Chaodan Shao, Yufen Xu, HongGang Jiang   +5 more
doaj   +1 more source

Genetic associations with childhood brain growth, defined in two longitudinal cohorts [PDF]

, 2018
Genome-wide association studies (GWASs) are unraveling the genetics of adult brain neuroanatomy as measured by cross-sectional anatomic magnetic resonance imaging (aMRI). However, the genetic mechanisms that shape childhood brain development are, as yet,
Jansen, Philip R., Justice, Cristina M., Muetzel, Ryan L., Sabourin, Jeremy A., Schwantes-An, Tae-Hwi Linus, Sharp, Wendy, Shaw, Philip, Sung, Heejong, Szekely, Eszter, Tiemeier, Henning, White, Tonya J., Wilson, Alexander F.   +11 more
core   +1 more source