Results 121 to 130 of about 441,826 (314)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Characterization of Walls Are Thin 1 Family in Cucumis sativus and Functional Identification of CsWAT1-20 in Response to Podosphaera xanthii

Horticulturae
Cucumber (Cucumis sativus) is an economically important vegetable but powdery mildew (caused by Podosphaera xanthii) limits cucumber production. The WALLS ARE THIN1 (WAT1) gene is crucial for regulating secondary cell wall thickness and is pivotal in ...
Jinghang Hong, Hongyan Zhao, Youmei Yuan, Jinming Wu, Yang Yu, Na Cui, Xiangnan Meng, Haiyan Fan   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Systematic analysis of genomic alterations in prostate cancer

, 2011
PhDProstate cancer is the most common male cancer in Western countries. The genetic mechanism underlying its initiation and progression is still unclear.
Mao, Xueying
core  

Trans-ethnic comprehensive genomic cluster stratification of upper tract urothelial carcinoma

[[abstract]]Introduction & Objectives: Previous genomic studies on upper tract urothelial carcinoma (UTUC) revealed characteristics compared to urinary bladder urothelial carcinoma (UBUC), but no endemic and epidemiologic specialties.
Wei, TC;Lin, YF;Luo, HL;Chang, YH;Ohyama, C;Hatakeyama, S;Huang, WJ;Wang, HJ;Yoneyama, T;Tsai, SF
core   +1 more source

Mapping of Multiple DNA Gains and Losses in Primary Small Cell Lung Carcinomas by Comparative Genomic Hybridization [PDF]

, 1994
Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens.
Speicher, Michael R., Cremer, Thomas, Petersen, Iver, Ried, Thomas, Manoir, Stanislas du, Schröck, Evelin, Holtgreve-Grez, Heidi   +6 more
core  

Genomic and functional characterization of coleopteran insect-specific α-amylase inhibitor gene from Amaranthus species

, 2017
The smallest 32 amino acid α-amylase inhibitor from Amaranthus hypochondriacus (AAI) is reported. The complete gene of pre-protein (AhAI) encoding a 26 amino acid (aa) signal peptide followed by the 43 aa region and the previously identified 32 aa ...
Amey J. Bhide, Ashok P. Giri, Vidya S. Gupta, Gupta, Vidya S., V. L. Maheshwari, Giri, Ashok P., Kabita Bhattacharjee, Channale, Sonal M., Yashpal Yadav, Pankaj K. Pawar, Pawar, Pankaj K., Ramasamy, Sureshkumar, Bhide, A., Maheshwari, V. L., Sureshkumar Ramasamy, Yadav, Yashpal, Sonal M. Channale, Bhattacharjee, Kabita   +17 more
core   +1 more source

Construction and characterization of a Lipotes vexillifer genomic DNA BAC library

, 2007
We constructed a genomic DNA library for Lipotes vexillifer (L. vexillifer), the Baiji or Yangtze River dolphin, one of the most endangered mammals in the world.
Zhang, Xian-feng, Fang, Sheng-guo, Wang, D, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China, Wang, Ding, Du, Bo   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

DNMTs are required for delayed genome instability caused by radiation [PDF]

, 2012
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, Rhona, Iyer Pooja (7605638), Sandhu, J, Talbot, CJ, Jatinderpal Sandhu (2369116), Narayanan, D, Singh, Rajinder, Tufarelli, Cristina, Anderson, RM, Iyer, P, Deepan Narayanan (7605641), Sandhu, Jatinderpal, Tufarelli, C, Rajinder Singh (246689), Singh, R, George D. Jones (7605635), R. Anderson (3529871), Armstrong, CA, Christopher J. Talbot (7581152), Iyer, Pooja, Jones, GD, C Tufarelli (7605644), Narayanan, Deepan, Christine A. Armstrong (7605632), Armstrong, Christine A., Jones, George Tripp, Talbot, Christopher J.   +26 more
core   +1 more source