Results 121 to 130 of about 2,956,729 (308)

Mapping of Multiple DNA Gains and Losses in Primary Small Cell Lung Carcinomas by Comparative Genomic Hybridization [PDF]

, 1994
Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens.
Speicher, Michael R., Cremer, Thomas, Petersen, Iver, Ried, Thomas, Manoir, Stanislas du, Schröck, Evelin, Holtgreve-Grez, Heidi   +6 more
core   +1 more source

Citrobacter braakii Isolated from Salami and Soft Cheese: An Emerging Food Safety Hazard?

Foods
Citrobacter braakii can colonize the intestinal tract of humans and animals and occasionally act as opportunistic pathogen. Although isolated from food and the environment, its potential as a foodborne pathogen remains uncertain. Twenty C.
Frédérique Pasquali, Cecilia Crippa, Alex Lucchi, Santolo Francati, Maria Luisa Dindo, Gerardo Manfreda   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Genomic designing for climate smart finger millet

, 2020
Finger millet is a nutritious cereal crop mainly grown in eastern Africa and southern parts of India. The crop has an incredible ability to adapt to adverse agro-ecological conditions, and is therefore a favorite of smallholder farmers in the tropics ...
Niazi, Adnan,, Sveriges lantbruksuniversitet.   +1 more
core   +1 more source

Characterization of Walls Are Thin 1 Family in Cucumis sativus and Functional Identification of CsWAT1-20 in Response to Podosphaera xanthii

Horticulturae
Cucumber (Cucumis sativus) is an economically important vegetable but powdery mildew (caused by Podosphaera xanthii) limits cucumber production. The WALLS ARE THIN1 (WAT1) gene is crucial for regulating secondary cell wall thickness and is pivotal in ...
Jinghang Hong, Hongyan Zhao, Youmei Yuan, Jinming Wu, Yang Yu, Na Cui, Xiangnan Meng, Haiyan Fan   +7 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Roles of pharmacists in cancer genomic medicine.

, 2020
The development of cancer genomic medicine has been embraced as an important new policy issue in “The 3rd Basic Plan to Promote Cancer Control Programs” formulated by the Japanese government.
675, 10324641, TERADA, Tomohiro, 寺田, 智祐   +3 more
core   +1 more source

Accuracy of multi-trait genomic selection using different methods [PDF]

, 2011
Background Genomic selection has become a very important tool in animal genetics and is rapidly emerging in plant genetics. It holds the promise to be particularly beneficial to select for traits that are difficult or expensive to measure, such as traits
Veerkamp Roel F, Calus, M.P.L., Roel F Veerkamp, Calus Mario PL, Veerkamp, R.F., Mario PL Calus   +5 more
core   +1 more source

Complete Genome and Characterization Analysis of a Bifidobacterium animalis Strain Isolated from Wild Pigs (Sus scrofa ussuricus)

Microorganisms
Bifidobacterium is a predominant probiotic in animals that is associated with host intestinal health. The protective mechanisms of the Bifidobacterium animalis (B.
Tenggang Di, Huan Zhang, Cheng Zhang, Liming Tian, Menghan Chang, Wei Han, Ruiming Qiao, Ming Li, Shuhong Zhang, Guangli Yang   +9 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source