Results 101 to 110 of about 441,826 (314)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Large-scale genetic variation of the symbiosis-required megaplasmid pSymA revealed by comparative genomic analysis of Sinorhizobium meliloti natural strains

, 2005
Giuntini E, Mengoni A, De Filippo C, et al. Large-scale genetic variation of the symbiosis-required megaplasmid pSymA revealed by comparative genomic analysis of Sinorhizobium meliloti natural strains. BMC Genomics.
Christian R Landry, Landry, Christian R., Duccio Cavalieri, Mengoni Alessio, Giuntini Elisa, Marco Bazzicalupo, Anke Becker, Giuntini, Elisa, Becker Anke, Elisa Giuntini, Nadia Aubin-Horth, Cavalieri, Duccio, Becker, Anke, Cavalieri Duccio, Bazzicalupo, Marco, Bazzicalupo Marco, De Filippo, Carlotta, Landry Christian R, Alessio Mengoni, De Filippo Carlotta, Carlotta De Filippo, Mengoni, Alessio, Aubin-Horth, Nadia, Aubin-Horth Nadia   +23 more
core   +1 more source

Genomic Characterization of Human DSPG3 [PDF]

Genome Research, 1999
DSPG3, the human homolog to chick PG-Lb, is a member of the small leucine-rich repeat proteoglycan (SLRP) family, including decorin, biglycan, fibromodulin, and lumican. In contrast to the tissue distribution of the other SLRPs, DSPG3 is predominantly expressed in cartilage.
M, Deere, J L, Dieguez, S J, Yoon, D, Hewett-Emmett, A, de la Chapelle, J T, Hecht   +5 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Screening and characterization of prophages in Desulfovibrio genomes [PDF]

Scientific Reports, 2018
AbstractBacteria of the genus Desulfovibrio belong to the group of Sulphate Reducing Bacteria (SRB). SRB generate significant liabilities in the petroleum industry, mainly due to their ability to microbiologically induce corrosion, biofilm formation and H2S production. Bacteriophages are an alternative control method for SRB, whose information for this
Josicelli Souza Crispim, Roberto Sousa Dias, Pedro Marcus Pereira Vidigal, Maíra Paula de Sousa, Cynthia Canêdo da Silva, Mateus Ferreira Santana, Sérgio Oliveira de Paula   +6 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A highly conserved gene island of three genes on chromosome 3B of hexaploid wheat: Diverse gene function and genomic structure maintained in a tightly linked block

, 2010
The complexity of the wheat genome has resulted from waves of retrotransposable element insertions. Gene deletions and disruptions generated by the fast replacement of repetitive elements in wheat have resulted in disruption of colinearity at a micro ...
Appels, Rudi, R., Paux, E., Feuillet, C., Paux Etienne, Wicker Thomas, Ma, W, Kong Xiuying, Kong, X., Breen, J., Xiuying Kong, Ma Wujun, Zhang, Juncheng, J., Ma, W., James M Breen, Breen, James, J., Kong, Xiuying, X., Catherine Feuillet, Breen, J, Juncheng, Z, Bellgard, Matthew, M., Kong, X, Zhang, J., Wicker, T., Appels Rudi, Matthew Bellgard, Zhang Juncheng, Bellgard, M, Thomas Wicker, Paux, Etienne, Breen James, Etienne Paux, James Breen, Wujun Ma, Bellgard Matthew, Appels, R, Bellgard, M., Ma, Wujun, W., Appels, R., Feuillet, C, Wicker, Thomas, T., Wicker, T, Feuillet, Catherine, C., Feuillet Catherine, Rudi Appels, Paux, E, Juncheng Zhang   +45 more
core   +1 more source

Characterization and Genome Sequence of the Mycobacteriophage Donny

Microbiology Resource Announcements, 2020
We report the discovery of the novel bacteriophage Donny, a Siphoviridae virus that infects Mycobacterium smegmatis mc 2 155. Donny has a genome length of 69,691 bp and a G+C content of 68.5%. Donny shares 99% and 93% nucleotide identity with bacteriophages Acadian and
Lauren E. Colston, Miriam Segura-Totten, Ryan A. Shanks   +2 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach

, 2009
Diaz NN, Krause L, Goesmann A, Niehaus K, Nattkemper TW. TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach. BMC Bioinformatics.
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Naryttza N Diaz, Lutz Krause, Krause, Lutz, Niehaus Karsten, Diaz Naryttza N, Goesmann, Alexander ; https://orcid.org/, Goesmann Alexander, Niehaus, Karsten, Tim W Nattkemper, Goesmann, Alexander, Karsten Niehaus, Diaz, Naryttza N., Nattkemper, Tim W., Krause Lutz, Alexander Goesmann   +16 more
core   +1 more source