Results 81 to 90 of about 821,530 (308)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Comprehensive characterization of neutrophil genome topology [PDF]

Genes & Development, 2017
Neutrophils are responsible for the first line of defense against invading pathogens. Their nuclei are uniquely structured as multiple lobes that establish a highly constrained nuclear environment. Here we found that neutrophil differentiation was not associated with large-scale changes in the number and sizes of topologically associating domains (TADs)
Zhu, Yina, Gong, Ke, Denholtz, Matthew, Chandra, Vivek, Kamps, Mark P., Alber, Frank, Murre, Cornelis   +6 more
openaire   +2 more sources

Characterization and Genomic Analysis of a Novel Jumbo Bacteriophage vB_StaM_SA1 Infecting Staphylococcus aureus With Two Lysins

Frontiers in Microbiology, 2022
The development of new antimicrobial agents is critically needed due to the alarming increase in antibiotic resistance in bacterial pathogens. Phages have been widely considered as effective alternatives to antibiotics.
Bingyan Zhang, Bingyan Zhang, Huzhi Sun, Feiyang Zhao, Qian Wang, Qiang Pan, Yigang Tong, Huiying Ren   +7 more
doaj   +1 more source

A new subfamily of fungal subtilases: structural and functional analysis of a Pleurotus ostreatus member [PDF]

, 2005
Pleurotus ostreatus produces several extracellular proteases which are believed to be involved in the regulation of the ligninolytic activities of this fungus. Recently, purification and characterization of the most abundant P.
FARACO, VINCENZA, FESTA, GIOVANNA, GIARDINA, PAOLA, MONTI, MARIA, PALMIERI G., SANNIA, GIOVANNI   +5 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Genomic Characterization of Metformin Hepatic Response [PDF]

PLOS Genetics, 2016
Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed for numerous other diseases. However, its mechanism of action in the liver has yet to be characterized in a systematic manner. To comprehensively identify genes and regulatory elements associated with metformin treatment, we carried out RNA-seq and ChIP-seq (H3K27ac ...
Eckalbar, Walter L., Giacomini, Kathleen M., Etheridge, Amy S., Wright, Fred, Laurance, Megan, Yee, Sook Wah, Smith, Robin P., Lin, Lawrence, Luizon, Marcelo R., Ahituv, Nadav, Innocenti, Federico, Gallins, Paul J., Jones, Stacy L., Wang, Yao, Molony, Cliona, Zhou, Yihui   +15 more
openaire   +5 more sources

Genomic Insights into Neglected Orthobunyaviruses: Molecular Characterization and Phylogenetic Analysis

Viruses
Orthobunyaviruses are a diverse group of segmented RNA viruses with significant but underexplored public and veterinary health implications. This study provides a genomic, phylogenetic, and ecological analysis of neglected Orthobunyaviruses using next ...
Safiétou Sankhe, Idrissa Dieng, Mouhamed Kane, Amadou Diallo, Ndeye Awa Ndiaye, Ndeye Marieme Top, Moussa Dia, Ousmane Faye, Amadou Alpha Sall, Oumar Faye, Pape Mbacke Sembene, Cheikh Loucoubar, Martin Faye, Moussa Moise Diagne   +13 more
doaj   +1 more source

Human infection with avian-origin H5N6 influenza a virus after exposure to slaughtered poultry

Emerging Microbes and Infections, 2022
Exposure to poultry in live poultry markets is strongly associated with human infection with avian influenza virus. To effectively prevent the transmission of viruses from live poultry to humans, people have been forced to change their living habits from
Jun Li, Yezhen Fang, Xiaofeng Qiu, Xinfen Yu, Shi Cheng, Na Li, Zhou Sun, Zhimin Ni, Haoqiu Wang   +8 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Genome Characterization of Gordonia Phage Amore2

Microbiology Resource Announcements, 2022
Novel Gordonia phage Amore2 was isolated from Pittsburgh, Pennsylvania and infects Gordonia terrae 3612. Amore2 was placed into Actinobacteria cluster CS1. Its genome is 73,842 bp with 105 predicted open reading frames and 56.6% GC content.
Caroline M. Lantis, Emily C. Mattison, Sarah E. Miller, Alexandria J. Williams, Alison E. Kanak   +4 more
openaire   +2 more sources