Results 81 to 90 of about 2,956,729 (308)

First isolation and characterization of a bovine parainfluenza virus type 3 genotype C strain from an aborted Holstein fetus

Frontiers in Veterinary Science
Bovine parainfluenza virus type 3 (BPIV3) is a significant pathogen responsible for bovine respiratory disease complex (BRDC) and reproductive disorders. Despite its importance, genomic studies of BPIV3 in abortion samples are currently lacking.
Yunxin Ren, Xi Chen, Cheng Tang, Hua Yue
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Genomic characterization in dilated cardiomyopathy

Revista Portuguesa de Cardiologia, 2019
© 2019 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.
openaire   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization [PDF]

, 1994
We analyzed 19 chromophobe renal cell carcinomas by means of comparative genomic hybridization. Two tumors revealed no numerical abnormalities. In the remaining 17 cases we found loss of entire chromosomes with underrepresentation of chromosome 1 ...
Speicher, Michael R., Cremer, Thomas, Kovacs, Gyula, Störkel, S., Ried, Thomas, Schoell, B., Manoir, Stanislas du, Schröck, Evelin   +7 more
core   +1 more source

A highly conserved gene island of three genes on chromosome 3B of hexaploid wheat: Diverse gene function and genomic structure maintained in a tightly linked block [PDF]

, 2010
The complexity of the wheat genome has resulted from waves of retrotransposable element insertions. Gene deletions and disruptions generated by the fast replacement of repetitive elements in wheat have resulted in disruption of colinearity at a micro ...
Appels, Rudi, R., Paux, E., Feuillet, C., Paux Etienne, Wicker Thomas, Ma, W, Kong Xiuying, Kong, X., Breen, J., Xiuying Kong, Ma Wujun, Zhang, Juncheng, J., Ma, W., James M Breen, Breen, James, J., Kong, Xiuying, X., Catherine Feuillet, Breen, J, Juncheng, Z, Bellgard, Matthew, M., Kong, X, Zhang, J., Wicker, T., Appels Rudi, Matthew Bellgard, Zhang Juncheng, Bellgard, M, Thomas Wicker, Paux, Etienne, Breen James, Etienne Paux, James Breen, Wujun Ma, Bellgard Matthew, Appels, R, Bellgard, M., Ma, Wujun, W., Appels, R., Feuillet, C, Wicker, Thomas, T., Wicker, T, Feuillet, Catherine, C., Feuillet Catherine, Rudi Appels, Paux, E, Juncheng Zhang   +45 more
core   +1 more source

Genomic Characterization of Differentiated Thyroid Carcinoma [PDF]

Endocrinology and Metabolism, 2019
Since the release of The Cancer Genome Atlas study of papillary thyroid carcinoma (PTC) in 2014, additional genomic studies of differentiated thyroid carcinoma (DTC) using massively-parallel sequencing (MPS) have been published. Recent advances in MPS technology have started to provide important insights into the molecular pathogenesis of DTC.
Young Shin Song, Young Joo Park
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Characterization of Twenty Sequenced Human Genomes

PLoS Genetics, 2010
We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals with severe hemophilia A and ten "control" genomes.
Pelak, Kimberly, Shianna, Kevin V., Ge, Dongliang, Maia, Jessica M., Zhu, Mingfu, Smith, Jason P., Cirulli, Elizabeth T., Fellay, Jacques, Dickson, Samuel P., Gumbs, Curtis E., Heinzen, Erin L., Need, Anna C., Ruzzo, Elizabeth K., Singh, Abanish, Campbell, C. Ryan, Hong, Linda K., Lornsen, Katharina A., McKenzie, Alexander M., Sobreira, Nara L. M., Hoover-Fong, Julie E., Milner, Joshua D., Ottman, Ruth, Haynes, Barton F., Goedert, James J., Goldstein, David B.   +24 more
openaire   +6 more sources

Genomic and pathogenic characterization of a highly pathogenic chicken infectious anemia virus strain in China

Frontiers in Veterinary Science
Chicken infectious anemia virus (CIAV) is a major immunosuppressive pathogen of poultry, causing aplastic anaemia, lymphoid atrophy, and severe haematopoietic dysfunction in young chicks, thereby posing a substantial threat to global poultry health and ...
Hongchun Yang, Liuyang Yuan, Hao Chen, Yue Liu, Aobo Xu, Ziqi Ling, Xiaoran Xuan, Shuangshuang Ma, Shufeng Feng, Yaping Wang, Hongbin Si, Gonghe Li, Yang Li, Anding Zhang, Changbo Ou, Changbo Ou, Changbo Ou   +16 more
doaj   +1 more source