Results 71 to 80 of about 441,826 (314)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Genomic characterization in dilated cardiomyopathy

Revista Portuguesa de Cardiologia, 2019
© 2019 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.
openaire   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Estimating quantitative genetic parameters in wild populations:A comparison of pedigree and genomic approaches [PDF]

, 2014
The estimation of quantitative genetic parameters in wild populations is generally limited by the accuracy and completeness of the available pedigree information. Using relatedness at genome-wide markers can potentially remove this limitation and lead to
Pemberton, Josephine M, Ellis, Philip A., Pemberton, Josephine M., Bérénos, Camillo, Ellis, Philip A, Pilkington, Jill G., Pilkington, Jill G   +6 more
core   +1 more source

Genomic characterization of novel Neisseria species [PDF]

Scientific Reports, 2019
AbstractOf the ten human-restrictedNeisseriaspecies two,Neisseria meningitidis, andNeisseria gonorrhoeae, cause invasive disease: the other eight are carried asymptomatically in the pharynx, possibly modulating meningococcal and gonococcal infections. Consequently, characterizing their diversity is important for understanding the microbiome in health ...
Kanny Diallo, Jenny MacLennan, Odile B. Harrison, Chisomo Msefula, Samba O. Sow, Doumagoum Moto Daugla, Errin Johnson, Caroline Trotter, Calman A. MacLennan, Julian Parkhill, Ray Borrow, Brian Greenwood, Martin C. J. Maiden   +12 more
openaire   +5 more sources

Genomic Insights into Neglected Orthobunyaviruses: Molecular Characterization and Phylogenetic Analysis

Viruses
Orthobunyaviruses are a diverse group of segmented RNA viruses with significant but underexplored public and veterinary health implications. This study provides a genomic, phylogenetic, and ecological analysis of neglected Orthobunyaviruses using next ...
Safiétou Sankhe, Idrissa Dieng, Mouhamed Kane, Amadou Diallo, Ndeye Awa Ndiaye, Ndeye Marieme Top, Moussa Dia, Ousmane Faye, Amadou Alpha Sall, Oumar Faye, Pape Mbacke Sembene, Cheikh Loucoubar, Martin Faye, Moussa Moise Diagne   +13 more
doaj   +1 more source

Characterization and Genomic Analysis of a Novel Jumbo Bacteriophage vB_StaM_SA1 Infecting Staphylococcus aureus With Two Lysins

Frontiers in Microbiology, 2022
The development of new antimicrobial agents is critically needed due to the alarming increase in antibiotic resistance in bacterial pathogens. Phages have been widely considered as effective alternatives to antibiotics.
Bingyan Zhang, Bingyan Zhang, Huzhi Sun, Feiyang Zhao, Qian Wang, Qiang Pan, Yigang Tong, Huiying Ren   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Genomic Characterization of Campylobacter jejuni strain M1 [PDF]

, 2010
Campylobacter jejuni strain M1 (laboratory designation 99/308) is a rarely documented case of direct transmission of C. jejuni from chicken to a person, resulting in enteritis. We have sequenced the genome of C.
Toszeghy, Monique, Wassenaar, TM, Javed Muhammad A., Trudy M Wassenaar, Muhammad A. Javed, Ridley, A, Toszeghy Monique, Trudy M. Wassenaar, Wassenaar, Gertrude Maria, Manning, Georgia, Carsten Friis, Newell, Diane G., Ussery, David, Snipen, L, Hallin, PF, Javed, Muhammad A., Newell, DG, Monique Toszeghy, Peter F Hallin, Snipen Lars, Hallin Peter F., David W. Ussery, Manning, G, Toszeghy, M, Ussery, DW, Georgina Manning, Friis Carsten, Lagesen, K, Friis, C, Ussery David W., Muhammad A Javed, Javed, MA, Newell Diane G., Friis, Carsten, Lagesen Karin, Diane G Newell, Lars Snipen, Peter F. Hallin, Anne Ridley, Lagesen, Karin, Ridley, Anne, Manning Georgina, David W Ussery, Diane G. Newell, Hallin, Peter Fischer, Wassenaar Trudy M., Snipen, Lars, Karin Lagesen, Ridley Anne   +48 more
core   +1 more source