Results 61 to 70 of about 2,956,729 (308)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Meeting report : 1st international functional metagenomics workshop May 7–8, 2012, St. Jacobs, Ontario, Canada [PDF]

, 2012
This report summarizes the events of the 1st International Functional Metagenomics Workshop. The workshop was held on May 7 and 8 in St. Jacobs, Ontario, Canada and was focused on building a core international functional metagenomics community, exploring
David R. Rose, Charles, Trevor, Valla, Svein, Reid, Alexandra, Kornelia Smalla, John Doemer, Edwards, Elizabeth A., Smalla, K., Alexandra Reid, Katja Engel, Moreno-Hagelsieb, Gabriel, Charles, Trevor C., Cheng-Cang Wu, Trevor C. Charles, Reid, A., Sean F. Brady, Sjöling, Sara, Liles, Mark R., Brady, Sean F., Sara Sjöling, Sjöling, Sara,, David A. Mead, Eric C. Martens, O’gara, Fergal, Streit, Wolfgang R., Sessitsch, Angela, Wellington, Elizabeth M.H., Edwards, E. A., Simonet, Pascal, Jennifer Tedman-Jones, O’Gara, F., Neufeld, Joseph D., Wolfgang R. Streit, Ashby, Deborah, Elizabeth A. Edwards, Wu, Cheng-Cang, Wellington, Elizabeth, Neufeld, Josh D., Fiebig, Klaus, Tedman-Jones, Jennifer, Martens, Erik C., Martens, Eric C., Angela Sessitsch, Engel, Katja, Doemer, John, Fergal O’Gara, Cowan, Don A., Miyazaki, Kentaro, Klaus Fiebig, Elizabeth M. H. Wellington, Pascal Simonet, Don A. Cowan, Rose, David R., Mark R. Liles, Smalla, Kornelia, Josh D. Neufeld, Wellington, Elizabeth M. H., Svein Valla, Kentaro Miyazaki, Gabriel Moreno-Hagelsieb, Deborah Ashby, Dennis McCormac, Wellington, E. M. H., McCormac, Dennis, O'Gara, Fergal, Mead, David A.   +65 more
core   +1 more source

Complete Genome Analysis of Highly Pathogenic Non-O1/O139 Vibrio cholerae Isolated From Macrobrachium rosenbergii Reveals Pathogenicity and Antibiotic Resistance-Related Genes

Frontiers in Veterinary Science, 2022
Non-O1/O139 Vibrio cholerae is a highly virulent pathogen that causes mass mortalities of various aquatic animals. In the present study, we sequenced the whole genome of non-O1/O139 V.
Yifan Zhou, Shuwen Gu, Jie Li, Peng Ji, Yingjie Zhang, Congcong Wu, Qun Jiang, Xiaojian Gao, Xiaojun Zhang   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Genomic Selective Constraints in Murid Noncoding DNA [PDF]

, 2006
Recent work has suggested that there are many more selectively constrained, functional noncoding than coding sites in mammalian genomes. However, little is known about how selective constraint varies amongst different classes of noncoding DNA.
Peter D Keightley, Daniel J Gaffney, Gaffney Daniel J, Keightley, Peter, Keightley Peter D, Gaffney, Daniel   +5 more
core   +2 more sources

Comparative Molecular Characterization of Novel and Known Piscine Toti-Like Viruses

Viruses, 2021
Totiviridae is a virus family well known to infect uni-cellular organisms like fungi and protozoa. In more recent years, viruses characterized as toti-like viruses, have been found in primarily arthropods, but also a couple in planarians and piscine ...
Liv Sandlund, Sunil K. Mor, Vikash K. Singh, Soumesh K. Padhi, Nicholas B. D. Phelps, Stian Nylund, Aase B. Mikalsen   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Genomic and transcriptional analysis of allergen genes in apple (Malus x domestica) [PDF]

, 2010
Apple consumption is highly recomended for a healthy diet and is the most important fruit produced in temperate climate regions. Unfortunately, it is also one of the fruit that most ofthen provoks allergy in atopic patients and the only treatment ...
Pagliarani, Giulia <1981>
core   +1 more source

Genomic characterization of a Chinese bovine papillomavirus isolate and its L1-based phylogenetic placement in a global dataset

Frontiers in Veterinary Science
IntroductionBovine papillomatosis (BP), caused by bovine papillomavirus (BPV), is characterized by proliferative epithelial lesions and is associated with significant economic losses in cattle populations. Despite its clinical and economic relevance, the
Yusheng Lin, Weiwei Liu, Jinxiu Jiang, Kul Raj Rai, Yongliang Che   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source