Results 91 to 100 of about 2,956,729 (308)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A global network for investigating the genomic epidemiology of malaria.

, 2008
Large-scale studies of genomic variation could assist efforts to eliminate malaria. But there are scientific, ethical and practical challenges to carrying out such studies in developing countries, where the burden of disease is greatest.
Malaria Genomic Epidemiology Network, Malaria Genomic Epidemiology
core   +1 more source

TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach [PDF]

, 2009
Diaz NN, Krause L, Goesmann A, Niehaus K, Nattkemper TW. TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach. BMC Bioinformatics.
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Naryttza N Diaz, Lutz Krause, Krause, Lutz, Niehaus Karsten, Diaz Naryttza N, Goesmann, Alexander ; https://orcid.org/, Goesmann Alexander, Niehaus, Karsten, Tim W Nattkemper, Goesmann, Alexander, Karsten Niehaus, Diaz, Naryttza N., Nattkemper, Tim W., Krause Lutz, Alexander Goesmann   +16 more
core   +1 more source

Genomic Characterization of the First Parechovirus in Bats [PDF]

Virologica Sinica, 2019
As important hosts for several pathogenic viruses, bats harbor viruses from almost all families of vertebrate viruses, including several genera of family Picornaviridae, including Hepatovirus, Kobuvirus, Crohivirus, and Sapelovirus ( Drexler et al. 2015 ; Wu et al. 2016 ; Yinda et al. 2017 ).
Chang Zhang, Jinliang Sheng, Zihan Zhao, Chao Yan, Changchun Tu, Biao He   +5 more
openaire   +2 more sources

Epidemiological characteristics and structural-functional implications of spike protein variations in a bovine coronavirus isolate from diarrheic calves

Virulence
Bovine coronavirus (BCoV) is an important pathogen associated with enteric disease in calves, contributing to significant economic losses worldwide. To provide an updated overview of BCoV epidemiology, we conducted a systematic review and meta-analysis ...
Fei Teng, Xiaoman Li, Hongzhe Zhao, Yingying Ma, Yingchun Wang, Mingze Chen, Wei Wu, Ting Xiao, Yuxin Wei, Sen Gao, Xinrui Li, Changcheng Zhu, Guiwei Li, Yanping Jiang, Jiaxuan Li, Wen Cui, Xinyuan Qiao   +16 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Integrated genomic characterization of oesophageal carcinoma [PDF]

Nature, 2017
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations.
Kim, Jihun, Bowlby, Reanne, Mungall, Andrew J., Robertson, A. Gordon, Odze, Robert D., Cherniack, Andrew D., Shih, Juliann, Pedamallu, Chandra Sekhar, Cibulskis, Carrie, Dunford, Andrew, Meier, Samuel R., Kim, Jaegil, Raphael, J., Wu, Hsin Ta, Wong, Alexandra M., Willis, Joseph E., Bass, Adam J., Derks, Sarah, Garman, Katherine, McCall, Shannon J., Wiznerowicz, MacIej, Pantazi, Angeliki, Parfenov, Michael, Thorsson, Vésteinn, Shmulevich, Ilya, Dhankani, Varsha, Miller, Michael, Sakai, Ku Leuven Ryo, Wang, Kenneth, Schultz, Nikolaus, Shen, Ronglai, Arora, Arshi, Weinhold, Nils, Sánchez-Vega, Francisco, Kelsen, David P., Zhang, Julia, Felau, Ina, Demchok, John, Rabkin, Charles S., Camargo, M. Constanza, Zenklusen, Jean Claude, Bowen, Jay, Leraas, Kristen, Lichtenberg, Tara M., Curtis, Christina, Seoane, Jose A., Ojesina, Akinyemi I., Beer, David G., Gulley, Margaret L., Pennathur, Arjun, Luketich, James D., Zhou, Zhongren, Weisenberger, Daniel J., Akbani, Rehan, Lee, Ju Seog, Liu, Wenbin, Mills, Gordon B., Zhang, Wei, Reid, Brian J., Hinoue, Toshinori, Laird, Peter W., Shen, Hui, Piazuelo, M. Blanca, Schneider, Barbara G., McLellan, Michael, Taylor-Weiner, Amaro, Lawrence, Michael, Cibulskis, Kristian, Stewart, Chip, Getz, Gad, Lander, Eric, Gabriel, Stacey B., DIng, Li, McLellan, Michael D., Miller, Christopher A., Appelbaum, Elizabeth L., Cordes, Matthew G., Fronick, Catrina C., Fulton, Lucinda A., Mardis, Elaine R., Wilson, Richard K., Schmidt, Heather K., Fulton, Robert S., Ally, Adrian, Balasundaram, Miruna, Carlsen, Rebecca, Chuah, Eric, Dhalla, Noreen, Holt, Robert A., Jones, Steven J.M., Kasaian, Katayoon, Brooks, Denise, Li, Haiyan I., Ma, Yussanne, Marra, Marco A., Mayo, Michael, Moore, Richard A., Mungall, Karen L., Schein, Jacqueline E., Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Wong, Tina, Beroukhim, Rameen, Bullman, Susan, Murray, Bradley A., Saksena, Gordon, Schumacher, Steven E., Meyerson, Matthew, Hadjipanayis, Angela, Kucherlapati, Raju, Ren, Xiaojia, Park, Peter J., Lee, Semin, Kucherlap, Melanie, Yang, Lixing, Baylin, Stephen B., Hoadley, Katherine A., Bootwalla, Moiz S., Lai, Phillip H., Den Berg, David J.Van, Berrios, Mario, Holbrook, Andrea, Hwang, Jun Eul, Jang, Hee Jin, Weinstein, John N., Lu, Yiling, Sohn, Bo Hwa, Seth, Sahil, Protopopov, Alexei, Bristow, Christopher A., Mahadeshwar, Harshad S., Tang, Jiabin, Song, Xingzhi, Zhangw, Jianhua, Cho, Juok, Defrietas, Timothy, Frazer, Scott, Gehlenborg, Nils, Heiman, David I., Lawrence, Michael S., Lin, Pei, Noble, Michael S., Voet, Doug, Zhang, Hailei, Polak, Paz, Chin, Lynda, Raphae, Benjamin J., Bernard, Brady, Iype, Lisa, Reynolds, Sheila M., Abeshouse, Adam, Armenia, Joshua, Kundra, Ritika, Ladanyi, Marc, Lehmann, Kjong Van, Gao, Jianjiong, Sander, Chris, Chakravarty, Debyani, Zhang, Hongxin, Radenbaugh, Cruz Amie, Hegde, Apruva, Penny, Robert, Crain, Daniel, Gardner, Johanna, Curley, Erin, Mallery, David, Morris, Scott, Paulauskis, Joseph, Shelton, Troy, Shelton, Candace, Frick, Jessica, Gastier-Foster, Julie M., Gerken, Mark, Leraas, Kristen M., Ramirez, Nilsa C., Wise, Lisa, Zmuda, Erik, Tarvin, Katherine, Saller, Charles, Park, Young Soo, Button, Michael, Carvalho, Andre L., Reis, Rui Manuel, Matsushita, Marcus Medeiros, Lucchesi, Fabiano, De Oliveira, Antonio Talvane, Le, Xuan, Paklina, Oxana, Setdikova, Galiya, Lee, Jae Hyuck, Bennett, Joseph, Iacocca, Mary, Huelsenbeck-DIll, Lori, Potapova, Cureline Olga, Voronina, Olga, Liu, Ouida, Fulidou, Victoria, Sharp, Alexis, Behera, Madhusmitara, Sica, Gabriel, Knox, Jennifer, Liu, Geoffrey, Boussioutas, Alex, Carlotti, Carlos Gilberto, Sankarankutty, Ajith Kumar, Dos Santos, Jose Sebastiaõ, Dubina, Michael, Reilly, Colleen, Ferrer-Torres, Daysha, Ajani, Jaffer A., Cheong, Jae Ho, Tarnuzzer, Roy   +212 more
openaire   +6 more sources

Extensive pneumocephalus in a fatal central nervous system infection caused by NDM-1–producing carbapenem-resistant Klebsiella pneumoniae: a case report

Frontiers in Medicine
BackgroundCentral nervous system (CNS) infections caused by New Delhi metallo-β-lactamase-1 (NDM-1)-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) are rare but associated with extremely high mortality because of extensive antimicrobial ...
Chen Zhang, Chen Zhang, Ye Lu, Jun Ni, Lina Chen, Qi Li, Fangyu Yu, Xiaohong Zhou   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source