Results 131 to 140 of about 441,826 (314)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The genomic anchors of the human major histocompatibility complex [PDF]

, 2009
Eukaryotic chromatin is organised into a hierarchy of topologically constrained loop structures. Matrix Attachment Regions (MARs) are genomic sequences that mediate the anchoring of chromatin to the insoluble proteinaceous fraction of the nucleus known
Ottaviani, D., Ottaviani, D
core  

Characterization of 20 genomic-SSR makers in barley.

, 2014
Characterization of 20 genomic-SSR makers in barley.
Guoping Zhang (211879), Weihua Mao (174568), Feibo Wu (278645), Mian Zhang (104308)   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

HBx targets centrosomal protein TAX1BP2 to promote genomic instability

, 2015
Centrosome is a major microtubule-organizing centre for regulating spindle assembly and bipolarity.Evidence suggests that cancer is a multi-step accumulation process of genomic instability resulted from centrosome dysfunction.
Tang, HC, Li, SK, Lau, PY, Zhou, Y, Ching, YP   +4 more
core  

Genomic characterization of Globodera ellingtonae populations from Chile

, 2021
Genomic characterization of Globodera ellingtonae populations from ...
US Department of Agriculture (17855009)
core  

Using genomic repeats for phylogenomics: a case study in wild tomatoes ( Solanum section Lycopersicon : Solanaceae) [PDF]

, 2016
NERC© 2015 The Authors. Biological Journal of the Linnean Society published by John Wiley & Sons Ltd on behalf of Linnean Society of London This is an open access article under the terms of the Creative Commons Attribution License, which permits use ...
Saerkinen, T, Leitch, AR, Knapp, S, Dodsworth, S, Knapp, S., Leitch, A.R., Chase, MW, Dodsworth, Steven, Chase, M.W., Särkinen, T.   +9 more
core   +1 more source

Genomic and molecular characterization of preterm birth

Proceedings of the National Academy of Sciences, 2019
Significance Preterm birth (PTB) complications are the leading cause of long-term morbidity and mortality in children. The genetic and molecular characteristics of PTB and related disorders remain unclear. In this study, a family-based cohort of 791 family trios, including 270 PTB and 521 control families, was investigated by using whole ...
Theo A. Knijnenburg, Joseph G. Vockley, Nyasha Chambwe, David L. Gibbs, Crystal Humphries, Kathi C. Huddleston, Elisabeth Klein, Prachi Kothiyal, Ryan Tasseff, Varsha Dhankani, Dale L. Bodian, Wendy S. W. Wong, Gustavo Glusman, Denise E. Mauldin, Michael Miller, Joseph Slagel, Summer Elasady, Jared C. Roach, Roger Kramer, Kalle Leinonen, Jasper Linthorst, Rajiv Baveja, Robin Baker, Benjamin D. Solomon, Greg Eley, Ramaswamy K. Iyer, George L. Maxwell, Brady Bernard, Ilya Shmulevich, Leroy Hood, John E. Niederhuber   +30 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Integrated genomic characterization of endometrial carcinoma [PDF]

, 2013
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies.
Wilson, Richard K, Buda, Elizabeth, Holt, Robert A, Moore, Richard A, Park, Peter, Hirst, Carrie, Shi, Yan, Kalicki-Veizer, Joelle, Guin, Ranabir, Hernandez, Bryan, Hadjipanayis, Angela, Lander, Eric, Schein, Jacqueline E, Varhol, Richard J, Salvesen, Helga B, Chin, Lynda, Hoadley, Katherine A, Sipahimalani, Payal, Sivachenko, Andrey, Carter, Candace, Bodenheimer, Tom, Balu, Saianand, Chun, Hye-Jung E, Baylin, Stephen B, Bootwalla, Moiz S, Birol, Inanc, Mayo, Michael, Perou, Charles M, Cibulskis, Kristian, Tam, Angela, O’Laughlin, Michelle, Chu, Andy, Gentry, Jeff, Li, Haiyan I, Xi, Ruibin, Jones, Steven JM, Topal, Michael D, Cherniack, Andrew D, Simons, Janae V, Winckler, Wendy, Waring, Scot, Fulton, Lucinda, Carlsen, Rebecca, Jones, Corbin D, Wu, Junyuan, Chuah, Eric, Balasundaram, Miruna, Onofrio, Robert C, Protopopov, Alexei, Song, Xingzhi, Kucherlapati, Raju, Jefferys, Stuart R, Gabriel, Stacey B, Yang, Lixing, Zeng, Dong, Mahadeshwar, Harshad S, Dooling, David, Lawrence, Mike, Kandoth, Cyriac, Plettner, Patrick, Ardlie, Kristin, Schmidt, Heather, Gordon Robertson, A, Lee, Darlene, Roach, Jeff, Parker, Joel S, Butterfield, Yaron SN, Mieczkowski, Piotr A, Ding, Li, Tang, Jiabin, Neil Hayes, D, Meng, Shaowu, Saksena, Gordon, Tabak, Barbara, Beroukhim, Rameen, Schumacher, Steven E, Meyerson, Matthew, Pashtan, Itai, Tan, Donghui, Todd Auman, J, Sougnez, Carrie, Dhalla, Noreen, Seth, Sahil, Ye, Kai, McLellan, Michael D, Marra, Marco A, Mungall, Andrew J, Lee, Semin, Mardis, Elaine R, Mose, Lisle E, Soloway, Mathew G, Fulton, Robert, Ren, Xiaojia, Carter, Scott L, Zhang, Jianhua, Ally, Adrian, Getz, Gad, Hoyle, Alan P   +97 more
core   +1 more source