Results 281 to 290 of about 821,530 (308)
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High-resolution 3D genome characterization
Nature Reviews Genetics, 2021In a paper in Nature, Hua et al. report the Micro-Capture-C method for near-base-pair resolution characterization of chromosomal interactions in mammalian cells.
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Characterization of indels in poxvirus genomes
Virus Genes, 2010By comparing sets of variola virus (VARV) genomes and sets of vaccinia virus (VACV) genomes, it was found that the insertion and deletion of small pieces of DNA (3-25 nucleotides) were common events among these poxviruses. Insertion events were characterized by the creation of tandem direct repeats, whereas the deletion events generally took place ...
Danielle, Coulson, Chris, Upton
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Genomic and antigenic characterization of avipoxviruses
Virus Research, 1988A permanent cell line of avian origin, QT-35, was used for the propagation of avipoxvirus isolates, including juncopox, pigeon pox, and field and vaccine strains of fowlpox viruses. The genomes of these avipoxvirus isolates were compared by restriction enzyme analysis using BamHI and HindIII endonuclease digestion and subsequent agarose gel ...
W M, Schnitzlein +2 more
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Characterization of the Drugged Human Genome
Pharmacogenomics, 2007Human drug targets are a part of our genome of special relevance to human disease. However, the number and nature of drug target genes has not yet been conclusively assessed. We analyzed involvement in biochemical functions, biological processes and pathways, with chromosome, cellular and tissue distribution of the 392 human drug targets collected in ...
Martin, Lauss +3 more
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Integrated genomic characterization of adrenocortical carcinoma
Nature Genetics, 2014Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the adrenal gland. Despite overall poor prognosis, ACC outcome is heterogeneous. We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously ...
Assié, Guillaume +33 more
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Norwalk Virus Genome Cloning and Characterization
Science, 1990Major epidemic outbreaks of acute gastroenteritis result from infections with Norwalk or Norwalk-like viruses. Virus purified from stool specimens of volunteers experimentally infected with Norwalk virus was used to construct recombinant complementary DNA (cDNA) and derive clones representing most of the viral genome.
Jiang, X. +3 more
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Genetic and Genomic Characterization of Soles
2019Genome architecture of soles has been intensively explored in the last years, particularly with the arrival of Next Generation Sequencing (NGS) techniques. Hence, a large amount of transcriptomic and genomic data has been generated facilitating the identification of molecular markers and the development of expression tools required to decipher the ...
Manchado, Manuel +4 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
exaly
Modern developments in germline pharmacogenomics for oncology prescribing
Ca-A Cancer Journal for Clinicians, 2022Peter H O'donnell, Natalie M Reizine
exaly