Results 111 to 120 of about 26,875,751 (309)
IEEE AccessAccumulation modelling uses machine learning to discover the dynamics by which systems acquire discrete features over time. Many systems of biomedical interest show such dynamics: from bacteria acquiring resistances to sets of drugs, to patients ...
Kazeem A. Dauda +2 more
doaj +1 more source
Graph data modelling for genomic variants
, 2019 Genome variant analysis is performed on Variant Call Format (VCF) files. It can take days to process these files for genome analytics due to challenges such as loading the files for each user query and processing them to answer questions of interest.
Aizad, Sanna, Anjum, Ashiq
core
Privacy-Preserving Processing of Raw Genomic Data [PDF]
, 2014 Geneticists prefer to store patients' aligned, raw genomic data, in addition to their variant calls (compact and summarized form of the raw data), mainly because of the immaturity of bioinformatic algorithms and sequencing platforms.
Adam Molyneaux +9 more
core +3 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
BEKVAEM: INTEGRATIVE DATA EXPLORER FOR HI-C DATA
Journal of Bioinformatics and Genomics, 2019 Motivation: The browser-based visualization of Hi-C contact maps alongside complementary data tracks is a computationally challenging task and requires an efficient software implementation to run on small clients.
Андреас Хофманн +3 more
doaj +1 more source
Genomic distance under gene substitutions [PDF]
, 2011 Dias Vieira Braga M, Machado R, Ribeiro LC, Stoye J. Genomic distance under gene substitutions. BMC Bioinformatics. 2011;12(Suppl 9: Proc. of RECOMB-CG 2011): S8.Background: The distance between two genomes is often computed by comparing only the common
Stoye Jens +12 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
ComputationThis paper proposes and experimentally evaluates a multi-level CPU-oriented execution method for high-throughput portion-based processing of file-backed Variant Call Format (VCF) data and automated mutation classification.
Lesia Mochurad +3 more
doaj +1 more source
Genome informatics: taming the avalanche of genomic data.
Genome biology, 2005 A report on the fourth Cold Spring Harbor Laboratory/Wellcome Trust Conference on Genome Informatics, Hinxton, UK, 22-26 September 2004.
openaire +2 more sources