Results 101 to 110 of about 26,875,751 (309)
Group Normalization for Genomic Data
PLoS ONE, 2012 Data normalization is a crucial preliminary step in analyzing genomic datasets. The goal of normalization is to remove global variation to make readings across different experiments comparable. In addition, most genomic loci have non-uniform sensitivity to any given assay because of variation in local sequence properties.
Mahmoud Ghandi, Michael A Beer
openaire +4 more sources
The Journal of Applied Laboratory Medicine, 2020 Abstract Background Control charting is routine in the quality assurance of traditional clinical laboratory testing. Genomic tests are not typically managed by control charting. We examined control charting to monitor the performance of a clinical next-generation sequencing (NGS) assay.
Jing Xu +6 more
openaire +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
, 2021 Genomic prediction models may be used in plant breeding pipelines. They are often calibrated using multi-generation data and there is an open question of whether all available data or a subset of it should be used to calibrate genomic prediction models ...
Gowda, Manje +5 more
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Online data for: Genomic insights in Ascending Aortic Size and Distensibility
, 2021 This dataset contains online supplementary data for our paper 'Genomic insights in Ascending Aortic Size and Distensibility'. Please contact us, should there be any questions regarding this data.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ...
Benjamins, J (via Mendeley Data) +2 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Detection of Cisplatin Resistance in Bladder Cancer Using Machine Learning
IEEE AccessBladder Cancer (BC) is the ninth most common cancer worldwide, with cisplatin-based chemotherapy being a standard treatment. However, the emergence of cisplatin resistance poses significant challenges, contributing to high recurrence rates.
Moditha Reddy Jagannatha Reddy +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Genomic, Proteomic, and Metabolomic Data Integration Strategies
, 2015 Robust interpretation of experimental results measuring discreet biological domains remains a significant challenge in the face of complex biochemical regulation processes such as organismal versus tissue versus cellular metabolism, epigenetics, and ...
Kwanjeera Wanichthanarak +2 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source