Results 51 to 60 of about 26,875,751 (309)
Genomic selection in dairy cattle [PDF]
, 2011 The objectives of this Ph.D. thesis were (1) to optimise genomic selection in dairy cattle with respect to the accuracy of predicting total genetic merit and (2) to optimise a dairy cattle breeding program using genomic selection. The study was performed
Roos, A.P.W., de
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Clinical Interpretation of Genomic Variations
Turkish Journal of Hematology, 2016 Novel high-throughput sequencing technologies generate largescale genomic data and are used extensively for disease mapping of monogenic and/or complex disorders, personalized treatment, and pharmacogenomics.
Müge Sayitoğlu
doaj +1 more source
Journal of Statistical Software, 2022 We describe a new algorithm and R package for peak detection in genomic data sets using constrained changepoint models. These detect changes from background to peak regions by imposing the constraint that the mean should alternately increase then ...
Toby Dylan Hocking +3 more
doaj +1 more source
Genomic data visualization on the Web [PDF]
Bioinformatics, 2004 Abstract Many types of genomic data can be represented in matrix format, with rows corresponding to genes and columns corresponding to gene features. The heat map is a popular technique for visualizing such data, plotting the data on a two-dimensional grid and using a color scale to represent the magnitude of each matrix entry.
Wei Wu, William Stafford Noble
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ecology and EvolutionEnvironmental DNA (eDNA) analysis has become a popular conservation tool for detecting rare and elusive species. eDNA assays typically target mitochondrial DNA (mtDNA) due to its high copy number per cell and its ability to persist in the environment ...
Holly V. Nelson +6 more
doaj +1 more source
Building Infrastructure for African Human Genomic Data Management
Data Science Journal, 2019 Human genomic data are large and complex, and require adequate infrastructure for secure storage and transfer. The NIH and The Wellcome Trust have funded multiple projects on genomic research, including the Human Heredity and Health in Africa (H3Africa ...
Ziyaad Parker +6 more
doaj +1 more source
, 2018 This is the Supplemental Data associated with the article: J.S.Lee, L.Adler et al "Urea cycle dysregulation generates clinically relevant genomic and biochemical signatures." in ...
Lee, J (via Mendeley Data) +1 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source