Results 101 to 110 of about 421,782 (313)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit [PDF]

, 2015
Background: Cronobacter sakazakii is a member of the genus Cronobacter that has frequently been isolated from powdered infant formula (PIF) and linked with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis.
Farbos, A, McNally, A, Paszkiewicz, K, Alan McNally, Moore, Karen, Audrey Farbos, Forsythe, S, Forsythe, Stephen, Stephen Forsythe, Paszkiewicz, Konrad, Dickins, Ben, Masood, Naqash, Farbos, Audrey, Konrad Paszkiewicz, Moore, K, Ben Dickins, Karen Moore, McNally, Alan; id_orcid, Masood, N, Naqash Masood, Dickins, B   +20 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

For Genomes, Repetition Breeds Diversity

PLoS Biology, 2011
A long-time observation in genomes from bacteria to humans is that the level of nucleotide diversity varies from region to region within the genome. The sequence at some spots is virtually identical among all individuals in a population, while at other spots, variation abounds.
openaire   +4 more sources

Studies on polymorphic alu insertions and genomic diversity within the major histocompatibility complex

, 2005
After the initiation of the human genome sequencing project and the introduction of the field of 'bioinformatics', interest in human genetic diversity studies has been increased.
Dunn, David Suliman
core  

The future of collaborative precision oncology approaches in sub-Saharan Africa: learnings from around the globe

Frontiers in Oncology
As the projected incidence and mortality of cancer in Sub-Saharan Africa (SSA) rises to epidemic proportions, it is imperative that more is done to identify the genomic differences and commonalities between patients of African and European ancestry to ...
Amadou Gueye, Boutros Maroun, Amol Zimur, Tom Berkovits, Shen Mynn Tan   +4 more
doaj   +1 more source

Puzzling Over the Pneumococcal Pangenome

Frontiers in Microbiology, 2018
The Gram positive bacterium Streptococcus pneumoniae (pneumococcus) is a major human pathogen. It is a common colonizer of the human host, and in the nasopharynx, sinus, and middle ear it survives as a biofilm.
N. Luisa Hiller, N. Luisa Hiller, Raquel Sá-Leão, Raquel Sá-Leão   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Genomic Access to the Diversity of Fishes [PDF]

, 2020
AbstractThe number of fishes exceeds that of all other vertebrates both in terms of species numbers and in their morphological and phylogenetic diversity. They are an ecologically and economically important group and play an essential role as a resource for humans. This makes the genomic exploration of fishes an important area of research, both from an
openaire   +2 more sources

Genomic diversity and population structure of the Leonberger dog breed [PDF]

, 2020
Background: Leonberger is a giant dog breed formed in the 1850s in Germany. Its post-World War II popularity has resulted in a current global population of ~ 30,000 dogs.
Jagannathan, Vidya, Seefried, Franz R., Oliehoek, Pieter, Jagannathan, Vidhya, Drögemüller, Cord, Letko, Anna, Minor, Katie M., Mickelson, James R.   +7 more
core   +1 more source