Results 81 to 90 of about 421,782 (313)

Bacillus subtilis Genome Diversity [PDF]

Journal of Bacteriology, 2007
ABSTRACT Microarray-based comparative genomic hybridization (M-CGH) is a powerful method for rapidly identifying regions of genome diversity among closely related organisms. We used M-CGH to examine the genome diversity of 17 strains belonging to the nonpathogenic species Bacillus subtilis .
Earl, Ashlee M., Losick, Richard, Kolter, Roberto   +2 more
openaire   +4 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Comparative genomic and proteomic analyses of two Mycoplasma agalactiae strains: clues to the macro- and micro-events that are shaping mycoplasma diversity [PDF]

, 2010
Background: While the genomic era is accumulating a tremendous amount of data, the question of how genomics can describe a bacterial species remains to be fully addressed.
Christine Citti, Blanchard, Alain,, Barbe, Valérie, Claverol, Stéphane, Schenowitz, Chantal, Jacob, Daniel, Sagne, Évelyne, Barbe, V, Laurent X Nouvel, Aurélien Barré, Nouvel, Xavier, Blanchard, A, Chantal Schenowitz, Stéphane Claverol, Daniel Jacob, Mangenot, Sophie, Marenda, MS, Eveline Sagné, Barré, Aurélien, Nouvel, LX, Marenda, Marc, Valérie Barbe, Barré, A, Sirand-Pugnet, P, Blanchard, Alain, Sagné, E, Marenda, Marc S., Alain Blanchard, Blanchard, Alain, A., Citti, Christine, Sophie Mangenot, Claverol, S, Schenowitz, C, Citti, C, Nouvel, Laurent X., Pascal Sirand-Pugnet, Nouvel, Laurent-Xavier, Sirand-Pugnet, Pascal, Sagné, Eveline, Nouvel, Laurent Xavier, Marc S Marenda, Jacob, D, Mangenot, S   +42 more
core   +1 more source

Hybridisation and genomic diversity in British and Irish pigeons Columba livia

, 2023
Human introductions of animals and plants have caused a diverse array of conservation problems, including extinction by hybridisation. This results from interbreeding of non-native and native populations, causing genomic homogenisation.
William J. Smith, Clegg, Sonya, Smith, William, Smith, WJ, Clegg, SM, Sonya M. Clegg   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Large-scale genetic variation of the symbiosis-required megaplasmid pSymA revealed by comparative genomic analysis of Sinorhizobium meliloti natural strains

, 2005
Giuntini E, Mengoni A, De Filippo C, et al. Large-scale genetic variation of the symbiosis-required megaplasmid pSymA revealed by comparative genomic analysis of Sinorhizobium meliloti natural strains. BMC Genomics.
Christian R Landry, Landry, Christian R., Duccio Cavalieri, Mengoni Alessio, Giuntini Elisa, Marco Bazzicalupo, Anke Becker, Giuntini, Elisa, Becker Anke, Elisa Giuntini, Nadia Aubin-Horth, Cavalieri, Duccio, Becker, Anke, Cavalieri Duccio, Bazzicalupo, Marco, Bazzicalupo Marco, De Filippo, Carlotta, Landry Christian R, Alessio Mengoni, De Filippo Carlotta, Carlotta De Filippo, Mengoni, Alessio, Aubin-Horth, Nadia, Aubin-Horth Nadia   +23 more
core   +1 more source

Long-read sequencing for 29 immune cell subsets reveals disease-linked isoforms

Nature Communications
Alternative splicing events are a major causal mechanism for complex traits, but they have been understudied due to the limitation of short-read sequencing.
Jun Inamo, Akari Suzuki, Mahoko Takahashi Ueda, Kensuke Yamaguchi, Hiroshi Nishida, Katsuya Suzuki, Yuko Kaneko, Tsutomu Takeuchi, Hiroaki Hatano, Kazuyoshi Ishigaki, Yasushi Ishihama, Kazuhiko Yamamoto, Yuta Kochi   +12 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Genomic epidemiology of a protracted hospital outbreak caused by multidrug-resistant Acinetobacter baumannii in Birmingham, England [PDF]

, 2014
Background: Multidrug-resistant Acinetobacter baumannii commonly causes hospital outbreaks. However, within an outbreak, it can be difficult to identify the routes of cross-infection rapidly and accurately enough to inform infection control.
Chan, Jacqueline, Beryl Oppenheim, Chan, Jacqueline Z-M, Constantinidou, Chrystala, Bradley, Craig, Halachev, Mihail R, Pallen, Mark J, Pallen, Mark J., Nicola Cumley, Matthew Smith-Banks, Mihail R Halachev, Smith-Banks, Matthew, Halachev, Mihail R., Jacqueline Z-M Chan, Oppenheim, Beryl, Craig Bradley, Constantinidou, Chrystala I, Chrystala I Constantinidou, Cumley, Nicola, Mark J Pallen   +19 more
core   +1 more source

Water Buffalo Genomic Diversity

, 2022
Since the advent of molecular genetics, the analysis of polymorphic loci has been used to study diversity between and within species at all levels of biological complexity, including domestic animals. Following technological improvements, different types
Williams J. L., Colli L., Ajmone-Marsan P.   +2 more
core   +1 more source