Results 91 to 100 of about 421,782 (313)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Pseudomonas aeruginosa Genomic Structure and Diversity [PDF]

Frontiers in Microbiology, 2011
The Pseudomonas aeruginosa genome (G + C content 65-67%, size 5.5-7 Mbp) is made up of a single circular chromosome and a variable number of plasmids. Sequencing of complete genomes or blocks of the accessory genome has revealed that the genome encodes a large repertoire of transporters, transcriptional regulators, and two-component regulatory systems ...
Klockgether, Jens, Cramer, Nina, Wiehlmann, Lutz, Davenport, Colin F., Tümmler, Burkhard   +4 more
openaire   +3 more sources

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

, 2014
Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on ...
Studholme, David J., Holden, Mathew TG, Ong, C, Beacham, I, Parkhill, J, Harting, J, Chen, Swaine L., Mehershahi, K, Holden, Matthew T. G., Nandi, T, T.G. Holden, Matthew, Didelot, X, Peak, I, Baybayan, Primo, Peak, Ian, Sim, B, Hoon, CH, Nandi, Tannistha, Boddey, J, Boddey, Justin, Boddey, Justin A., Holden, Matthew, J. Studholme, David, Baybayan, P, Michell, S, Essex-Lopresti, AE, Guo, Yan, Sim, Bernice, Didelot, Xavier, Titball, Richard W., Chen, SL, Smither, Sophie, Smiters, Sophie, Beacham, Ifor, Holden, Matthew TG, Smither, S, How, LC, Nelson, Michelle, Ong, Catherine, Tan, P, Wang, S, Aw, LT, Nelson, M, Mitchell, Stephen, Michell, Stephen, Aw, Lay Tin, E. Essex-Lopresti, Angela, Chen, Swaine, Chen, Swaine L, Titball, Richard, Mehrashahi, Kurosh, Hoon, Chua Hui, Boddey, Justin A, Sarkar-Tyson, M, Parkhill, Julian, Mehershahi, Kurosh, Guo, Y, Tan, Patrick, How, Lee Chee, W. Titball, Richard, Sarkar-Tyson, Mitali, Wang, Susana, Essex-Lopresti, Angela, Studholme, David J, Harting, John   +64 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Retrotransposon Evolution in Diverse Plant Genomes [PDF]

Genetics, 2000
Abstract Retrotransposon or retrotransposon-like sequences have been reported to be conserved components of cereal centromeres. Here we show that the published sequences are derived from a single conventional Ty3-gypsy family or a nonautonomous derivative.
Langdon, T., Seago, C., Mende, M., Leggett, M., Thomas, H., Forster, J., Thomas, H., Jones, R., Jenkins, G.   +8 more
openaire   +3 more sources

Genomic diversity of citrate fermentation in Klebsiella pneumoniae

, 2009
Background It has long been recognized that Klebsiella pneumoniae can grow anaerobically on citrate. Genes responsible for citrate fermentation of K. pneumoniae were known to be located in a 13-kb gene cluster on the chromosome.
Huang I-Wen, Tsai Shih-Feng, Su Ih-Jen, Chen, YT; Liao, TL; Wu, KM; Lauderdale, TL; Yan, JJ; Huang, IW; Lu, MC; Lai, YC; Liu, YM; Shu, HY; Wang, JT; Su, IJ; Tsai, SF;, I-Wen Huang, Shu Hung-Yu, Liu Yen-Ming, Yen-Ming Liu, Jin-Town Wang, Yan Jing-Jou, Yi-Chyi Lai, Chen, YT;Liao, TL;Wu, KM;Lauderdale, TL;Yan, JJ;Huang, IW;Lu, MC;Lai, YC;Liu, YM;Shu, HY;Wang, JT;Su, IJ;Tsai, SF, Tsai-Lien Liao, Tsai-Ling Lauderdale, Min-Chi Lu, Ih-Jen Su, Lai Yi-Chyi, Liao Tsai-Lien, Lauderdale Tsai-Ling, Jing-Jou Yan, Keh-Ming Wu, Wu Keh-Ming, Ying-Tsong Chen, Shih-Feng Tsai, Chen Ying-Tsong, Lu Min-Chi, Wang Jin-Town, Hung-Yu Shu   +27 more
core   +1 more source

Whole-genome resequencing reveals genetic diversity, differentiation, and selection signatures of yak breeds/populations in southwestern China

Frontiers in Genetics
The Sichuan-Yunnan region is the main production area of yaks in southwestern China, with rich genetic resources of Yaks. Nevertheless, there have been limited study on the genetic characteristics of the entire yak populations in Tibet and southwestern ...
Shilin Zhang, Jing Li, Yanhua Zhao, Yujun Tang, Hao Li, Tianzeng Song, Tianwu An, Jiuqiang Guan, Xiaowei Li, Ming Zhang, Ming Zhang, Ming Zhang   +11 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of range expansions on current human genomic diversity

, 2014
The patterns of population genetic diversity depend to a large extent on past demographic history. Most human populations are known to have gone recently through a series of range expansions within and out of Africa, but these spatial expansions are ...
Excoffier, Laurent, Peischl, Stephan, Martins Conde e Sousa, Vitor   +2 more
core   +1 more source

Unveiling the role of phages in shaping the periodontal microbial ecosystem

mSystems
The oral microbiome comprises various species and plays a crucial role in maintaining the oral ecosystem and host health. Phages are an important component of the periodontal microbiome, yet our understanding of periodontal phages remains limited.
Fangfang Yao, Jiajun He, Raphael Nyaruaba, Hongping Wei, Yuhong Li   +4 more
doaj   +1 more source