Results 1 to 10 of about 305,735 (153)

Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure [PDF]

, 2017
The natural environment serves as a reservoir of opportunistic pathogens. A well-established method for studying the epidemiology of such opportunists is multilocus sequence typing, which in many cases has defined strains predisposed to causing infection.
Peeters, Charlotte, Cooper, Vaughn S, Hatcher, Philip J, Verheyde, Bart, Carlier, Aurélien, Vandamme, Peter   +5 more
core   +12 more sources

Global Distribution of mcr Gene Variants in 214K Metagenomic Samples

mSystems, 2022
Since the initial discovery of a mobilized colistin resistance gene (mcr-1), several other variants have been reported, some of which might have circulated a while beforehand.
Hannah-Marie Martiny, Patrick Munk, Christian Brinch, Judit Szarvas, Frank M. Aarestrup, Thomas Nordahl Petersen   +5 more
doaj   +1 more source

Benzodiazepine-related dementia risks and protopathic biases revealed by multiple-kernel learning with electronic medical records

Digital Health, 2023
Objectives To simultaneously estimate how the risk of incident dementia nonlinearly varies with the administration period and cumulative dose of benzodiazepines, the duration of disorders with an indication for benzodiazepines, and other potential ...
Takashi Hayakawa, Takuya Nagashima, Hayato Akimoto, Kimino Minagawa, Yasuo Takahashi, Satoshi Asai   +5 more
doaj   +1 more source

A Peek into the Plasmidome of Global Sewage

mSystems, 2021
This is, to the best of our knowledge, the first study to investigate plasmidomes at a global scale using long read sequencing from complex untreated domestic sewage.
Philipp Kirstahler, Frederik Teudt, Saria Otani, Frank M. Aarestrup, Sünje Johanna Pamp   +4 more
doaj   +1 more source

Genomic epidemiology of Vibrio cholerae reveals the regional and global spread of two epidemic non-toxigenic lineages [PDF]

, 2020
Non-toxigenic Vibrio cholerae isolates have been found associated with diarrheal disease globally, however, the global picture of non-toxigenic infections is largely unknown. Among non-toxigenic V.
Cui, Yujun, Didelot, Xavier, Pan, Jingcao, Sun, Zhou, Wang, Haoqiu, Wu, Yarong, Yang, Chao, Yang, Ruifu, Yu, Hua, Zhang, Wei, Zheng, Wei   +10 more
core   +1 more source

Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Nature Communications, 2022
Understanding the emergence, evolution, and transmission of antibiotic resistance genes (ARGs) is essential to combat antimicrobial resistance. Here, Munk et al. analyse ARGs in hundreds of sewage samples from 101 countries and describe regional patterns,
Patrick Munk, Christian Brinch, Frederik Duus Møller, Thomas N. Petersen, Rene S. Hendriksen, Anne Mette Seyfarth, Jette S. Kjeldgaard, Christina Aaby Svendsen, Bram van Bunnik, Fanny Berglund, Global Sewage Surveillance Consortium, D. G. Joakim Larsson, Marion Koopmans, Mark Woolhouse, Frank M. Aarestrup   +14 more
doaj   +1 more source

Combining genomics and epidemiology to track mumps virus transmission in the United States. [PDF]

, 2020
Unusually large outbreaks of mumps across the United States in 2016 and 2017 raised questions about the extent of mumps circulation and the relationship between these and prior outbreaks.
Bankamp, Bettina, Barreira, Paul, Burns, Meagan, Byrne, Elizabeth H, Chak, Bridget, Fitzgerald, Susan, Fleming, Stephen, Gharib, Soheyla, Grad, Yonatan H, Hennigan, Scott, Krasilnikova, Lydia A, Lett, Susan, Lewnard, Joseph A, MacInnis, Bronwyn L, Madoff, Lawrence C, Matranga, Christian B, McNall, Rebecca J, Metsky, Hayden C, Park, Daniel J, Piantadosi, Anne, Qu, James, Rota, Paul A, Sabeti, Pardis C, Sabina, Brandon, Schaffner, Stephen F, Shah, Rickey R, Siddle, Katherine J, Smole, Sandra, Wohl, Shirlee, Yozwiak, Nathan L   +29 more
core   +1 more source

Metagenomics analysis of bacteriophages and antimicrobial resistance from global urban sewage

Scientific Reports, 2021
Bacteriophages, or phages, are ubiquitous bacterial and archaeal viruses with an estimated total global population of 1031. It is well-known that wherever there are bacteria, their phage counterparts will be found, aiding in shaping the bacterial ...
Josephine E. S. Strange, Pimlapas Leekitcharoenphon, Frederik Duus Møller, Frank M. Aarestrup   +3 more
doaj   +1 more source

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]

, 2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.
A Dehghan, Aaron Isaacs, Abbas Dehghan, AD Johnson, AD Johnson, Afshin Parsa, Alan R Shuldiner, Albert Hofman, Albert V Smith, AM Bennet, Andre Uitterlinden, Andreas Ziegler, Angelo Scuteri, Anne B Newman, Arne Schillert, Ben Oostra, BM Psaty, Bolli Thorsson, Braxton D Mitchell, Bruce M Psaty, C Meisinger, C Sabatti, Caroline Hayward, Caroline S Fox, Charles C White, Christa Meisinger, Christie Ballantyne, Christopher J O'Donnell, Cornelia van Duijn, CS Fox, D Lloyd-Jones, D Wang, Daniel H O'Leary, David J Couper, DI Chasman, DI Chasman, E Falk, EB Mathiesen, Edward G Lakatta, Eran Halperin, Eric Boerwinkle, Eva-Maria Stoegerer, Fernando Rivadeneira, Florian Ernst, Georg Homuth, Gerardo Heiss, Gianluca Usala, Gonçalo R Abecasis, Gudny Eiriksdottir, H Erich Wichmann, H Schunkert, H Yasuda, Helena Schmidt, Henry Völzke, Hugh S Markus, Jacqueline Witteman, James F Wilson, Jan Lüdemann, Jennifer E Huffman, Jens Baumert, Jerome I Rotter, JH Stein, Joachim Thiery, Jochen Seissler, Jorma Viikari, Joseph F Polak, Joshua C Bis, K Stark, K Yuan, Kari North, Katja E Petrovic, Kenneth Rice, Kent Taylor, L Adrienne Cupples, L Paternoster, Leena Peltonen, Lenore J Launer, M Kolz, M Oguri, Manuela Uda, Marco Orru, Marcus Dörr, Maryam Kavousi, Matthias Sitzer, Mika Kähönen, Muredach P Reilly, MW Lorenz, N Soranzo, Nora Franceschini, Norman Klopp, Olli Raitakari, P Greenland, Philip A Wolf, Philipp S Wild, R Nakov, R Ross, Ralph B D'Agostino, Ravi Kumar Chilukoti, Reinhold Schmidt, Renate B Schnabel, S Kathiresan, S Kathiresan, Sekar Kathiresan, Serena Sanna, Serkalem Demissie, SH Johnsen, Stefan Blankenberg, Steve Bevan, Susan R Heckbert, T Rahman, TA Manolio, Tamara B Harris, Tanja Zeller, Terho Lehtimäki, Thomas Illig, Thomas Münzel, Thor Aspelund, Ulf Schminke, V Nambi, Vijay Nambi, Vilmundur Gudnason, W Insull Jr., Wendy S Post, Wolfgang Koenig, Wolfgang Rathmann, Xia Li, XZ Zhou, YS Aulchenko, Yu-Ching Cheng   +128 more
core   +8 more sources

Global Distribution and Diversity of Prevalent Sewage Water Plasmidomes

mSystems, 2022
Sewage water from around the world contains an abundance of short plasmids, several of which harbor antimicrobial resistance genes (ARGs). The global dynamics of plasmid-derived antimicrobial resistance and functions are only starting to be unveiled ...
Frederik Teudt, Saria Otani, Frank M. Aarestrup   +2 more
doaj   +1 more source