Results 101 to 110 of about 305,884 (298)

Tanzanian goat gut microbiomes adapt to roadside pollutants and environmental stressors

Microbiology Spectrum
The impact of environmental pollution reaching and affecting the gut microbiome is rising. Pollution from vehicle emissions can release compounds harmful to both animal and environmental health, and their effect on the host microbiome is yet to be ...
Emilie Egholm Bruun Jensen, Marie Louise Jespersen, Christina Aaby Svendsen, Tolbert Sonda, Saria Otani, Frank M. Aarestrup   +5 more
doaj   +1 more source

Aarskog-Scott syndrome: phenotypic and genetic heterogeneity

AIMS Genetics, 2016
Aarskog-Scott syndrome (AAS) is a rare developmental disorder which primarily affects males and has a relative prevalence of 1 in 25,000 in the general population.
Ignacio Briceno, Julio Martinez, M. Reza Jabalameli, Reuben J. Pengelly, Sarah Ennis, Andrew Collins   +5 more
doaj   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

Salmonella pathogenicity Island 1 undergoes decay in serovars adapted to swine and poultry

Microbiology Spectrum
Human salmonellosis is a high-priority foodborne disease worldwide. The main reservoir of Salmonella is livestock, mainly swine and poultry that are infected both by generalist serovars and serovars adapted to them.
Martina Tambassi, Melissa Berni, Chiara Bracchi, Ilaria Menozzi, Alessandra Dodi, Laura Mazzera, Marina Morganti, Erika Scaltriti, Stefano Pongolini   +8 more
doaj   +1 more source

Genomic fingerprinting in the epidemiology of gonorrhoea

Acta Dermato-Venereologica, 1985
We investigated the usefulness of the restriction enzyme (RE) fingerprinting for epidemiological tracing in gonococcal disease. The RE patterns of three paired gonococcal isolates showed corresponding identical fingerprints. Within each of the three pairs of epidemiologically linked isolates the respective restriction patterns were completely identical.
E S, Falk, D, Danielsson, B, Bjorvatn, K, Melby, B, Sørensen, B E, Kristiansen   +5 more
openaire   +2 more sources

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. [PDF]

, 2018
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10-7); of these, 16 map outside known risk-associated loci. We make two important
Afaq, Saima, Afzal, Shoaib, Ahlqvist, Emma, Almgren, Peter, Amin, Najaf, An, Ping, Bang, Lia B, Bertoni, Alain G, Bielak, Lawrence F, Bombieri, Cristina, Bork-Jensen, Jette, Brandslund, Ivan, Brody, Jennifer A, Burtt, Noël P, Canouil, Mickaël, Chen, Yii-Der Ida, Cho, Yoon Shin, Christensen, Cramer, Chu, Audrey Y, Cook, James P, de Haan, Hugoline G, Demirkan, Ayse, Eastwood, Sophie V, Eckardt, Kai-Uwe, ExomeBP Consortium, Fischer, Krista, Flannick, Jason, Gambaro, Giovanni, Gan, Wei, GIANT Consortium, Giedraitis, Vilmantas, Graff, Marielisa, Grarup, Niels, Grove, Megan L, Guo, Xiuqing, Gustafsson, Stefan, Hackinger, Sophie, Hai, Yang, Han, Sohee, Highland, Heather M, Hivert, Marie-France, Hu, Yao, Huo, Shaofeng, Isomaa, Bo, Jensen, Richard A, Justice, Anne E, Jäger, Susanne, Jørgensen, Marit E, Jørgensen, Torben, Kim, Bong-Jo, Kim, Sung Soo, Kim, Young Jin, Kitajima, Hidetoshi, Koistinen, Heikki A, Kovacs, Peter, Kravic, Jasmina, Kriebel, Jennifer, Kronenberg, Florian, Käräjämäki, Annemari, Lange, Leslie A, Lecoeur, Cécile, Lee, Jung-Jin, Lehne, Benjamin, Li, Huaixing, Li, Jin, Li, Man, Li-Gao, Ruifang, Ligthart, Symen, Lin, Keng-Hung, Liu, Dajiang J, Lohman, Kurt K, Lu, Yingchang, Läll, Kristi, MAGIC Consortium, Mahajan, Anubha, Malerba, Giovanni, Marouli, Eirini, Marten, Jonathan, Meidtner, Karina, Müller-Nurasyid, Martina, Peloso, Gina Marie, Preuss, Michael, Prins, Bram Peter, Rayner, N William, Robertson, Neil R, Rybin, Denis V, Smith, Albert Vernon, Steinthorsdottir, Valgerdur, Tajes, Juan Fernandez, Taliun, Daniel, Trubetskoy, Vassily Vladimirovich, Tybjærg-Hansen, Anne, Varga, Tibor V, Warren, Helen R, Wessel, Jennifer, Willems, Sara M, Wuttke, Matthias, Yaghootkar, Hanieh, Zhang, Weihua, Zhao, Wei   +99 more
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Biosafety and Genomic Epidemiological Surveillance

Epidemiology and Vaccinal Prevention
The problem of biological safety is extremely relevant today for all countries of the world because of the real and potential threats caused by biological agents that are dangerous to public health and the environment. Modern microorganisms are becoming increasingly aggressive towards humans, as clearly demonstrated by the COVID-19 pandemic, which has ...
V. G. Akimkin, T. A. Semenenko, K. F. Khafizov, S. V. Ugleva, D. V. Dubodelov, E. D. Sverdlov, A. S. Cherkashina, G. A. Gasanov, M. I. Nadtoka, N. P. Rumyantseva, Yu. V. Mikhailova, A. A. Shelenkov, A. S. Esman, I. V. Alekseenko, L. G. Kondratyeva, R. M. Beregovykh   +15 more
openaire   +2 more sources

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, EarlyView.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

Emerging Challenges and Opportunities in Infectious Disease Epidemiology. [PDF]

, 2019
Much of the intellectual tradition of modern epidemiology stems from efforts to understand and combat chronic diseases persisting through the 20th century epidemiologic transition of countries such as the United States and United Kingdom.
Lewnard, Joseph A, Reingold, Arthur L
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