Results 81 to 90 of about 1,050,824 (300)

Replication Data for: Genomic epidemiology of the rotavirus G2P[4] strains in coastal Kenya pre- and post-rotavirus introduction, 2012-2018

, 2022
This is a replication dataset for the manuscript titled: "Genomic epidemiology of the rotavirus G2P[4] strains in coastal Kenya pre- and post-rotavirus introduction, 2012-2018." The dataset is part of the study investigating genomic epidemiology of ...
Lambisia, Arnold W., Agoti, Charles N., Laurent, Zaydah R. de, Murunga, Nickson, Lewa, Clement S., Bargul, Joel L., Mwanga, Mike J., Cotten, Matthew, Nokes, D. James, Mutunga, Martin, Phan, My, Makori, Timothy O.   +11 more
core   +2 more sources

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

A Network of Investigator Networks in Human Genome Epidemiology [PDF]

American Journal of Epidemiology, 2005
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors propose the creation of a network of networks that include groups of investigators collecting data for human genome epidemiology research.
Ioannidis, J. P. A., Bernstein, J., Boffetta, P., Danesh, J., Dolan, S., Hartge, P., Hunter, D., Inskip, P., Jarvelin, M. -R., Little, J., Maraganore, D. M., Newton Bishop, J. A., O'Brien, T. R., Petersen, G., Riboli, E., Seminara, D., Taioli, E., Uitterlinden, A. G., Vineis, P., Winn, D. M., Salanti, G., Higgins, J. P. T., Khoury, M. J.   +22 more
openaire   +4 more sources

Predicting Single‐Cell Perturbation Responses Across Biological Contexts With a Deep Generative Model Integrating Optimal Transport

Advanced Science, EarlyView.
Single‐cell perturbation responses are predicted across held‐out biological contexts using scPILOT, a query‐conditioned two‐stage latent response‐transfer framework. A shared latent representation supports cell‐level response estimation by latent optimal transport, followed by Leiden‐localized query‐specific transfer and adaptive weighting.
Jialiang Wang, Ziqi Liu, Zhengqian Zhang, Yikun Cao, Junjun Ren, Peng Cheng, Jingjing Tian, Lingyun Xie, Xin Lu, Zhanwei Du, Yongzhuang Liu   +10 more
wiley   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Addressing Learning Needs on the Use of Metagenomics in Antimicrobial Resistance Surveillance

Frontiers in Public Health, 2020
One Health surveillance of antimicrobial resistance (AMR) depends on a harmonized method for detection of AMR. Metagenomics-based surveillance offers the possibility to compare resistomes within and between different target populations.
Ana Sofia Ribeiro Duarte, Katharina D. C. Stärk, Patrick Munk, Pimlapas Leekitcharoenphon, Alex Bossers, Alex Bossers, Roosmarijn Luiken, Steven Sarrazin, Oksana Lukjancenko, Sünje Johanna Pamp, Valeria Bortolaia, Jakob Nybo Nissen, Philipp Kirstahler, Liese Van Gompel, Casper Sahl Poulsen, Rolf Sommer Kaas, Maria Hellmér, Rasmus Borup Hansen, Violeta Munoz Gomez, Tine Hald   +19 more
doaj   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

MAGICIAN: MAG simulation for investigating criteria for bioinformatic analysis

BMC Genomics
Background The possibility of recovering metagenome-assembled genomes (MAGs) from sequence reads allows for further insights into microbial communities and their members, possibly even analyzing such sequences with tools designed for single-isolate ...
Kat Steinke, Sünje J. Pamp, Patrick Munk   +2 more
doaj   +1 more source

PolyTB: a genomic variation map for Mycobacterium tuberculosis [PDF]

, 2014
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second major cause of death from an infectious disease worldwide. Recent advances in DNA sequencing are leading to the ability to generate whole genome information in clinical isolates ...
Gagneux, S., Perdigão, João, McNerney, R., Glynn, Judith R., McNerney, Ruth, Preston, M., Perdigao, J., Gagneux, Sebastien, Viveiros, M., Glynn, Judith R, Guerra-Assunção, José Afonso, Glynn, J., Parkhill, J., Harris, D., Clark, T., Coll, Francesc, Viveiros, Miguel, Hill-Cawthorne, G., Hill-Cawthorn, Grant, Pain, A., Pain, Arnab, Clark, Taane G., Portugal, I., Parkhill, Julian, Preston, Mark, Drobniewski, Francis, Drobniewski, F., Portugal, Isabel, Martin, Nigel, Guerra-Assuncao, J., Harris, David, Coll, F., Clark, Taane G   +32 more
core   +1 more source