Results 101 to 110 of about 1,050,824 (300)

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Design of Prospective Meta-Analyses of Genome-Wide Association Studies From 5 Cohorts

, 2009
Background-The primary aim of genome-wide association studies is to identify novel genetic loci associated with interindividual variation in the levels of risk factors, the degree of subclinical disease, or the risk of clinical disease.
Witteman, JCM, Uitterlinden, André, Lunetta, KL, Boerwinkle, E, Psaty, BM, Uitterlinden, André; id_orcid, Folsom, AR, Gudnason, V, O'Donnell, CJ, Rotter, JI, Harris, TB   +10 more
core   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Role of genomic typing in taxonomy, evolutionary genetics, and microbial epidemiology. [PDF]

, 2001
Currently, genetic typing of microorganisms is widely used in several major fields of microbiological research. Taxonomy, research aimed at elucidation of evolutionary dynamics or phylogenetic relationships, population ...
Struelens, M., Michel Tibayrenc, Verburgh, H., Verbrugh, H.A. (Henri), Belkum, A., van, Belkum, A.F. (Alex) van, Tibayrench, M., Arjan de Visser, Visser, J.A.G.M., de, Henri Verbrugh, Visser, A. (Arjan) de, Marc Struelens, Tibayrenc., M., Alex van Belkum, Tibayrenc, M, Struelens, MJ, Belkum, Alex, de Visser, A, Verbrugh, Henri   +18 more
core   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Salmonella pathogenicity Island 1 undergoes decay in serovars adapted to swine and poultry

Microbiology Spectrum
Human salmonellosis is a high-priority foodborne disease worldwide. The main reservoir of Salmonella is livestock, mainly swine and poultry that are infected both by generalist serovars and serovars adapted to them.
Martina Tambassi, Melissa Berni, Chiara Bracchi, Ilaria Menozzi, Alessandra Dodi, Laura Mazzera, Marina Morganti, Erika Scaltriti, Stefano Pongolini   +8 more
doaj   +1 more source

Bacterial genomic epidemiology, from local outbreak characterization to species-history reconstruction [PDF]

, 2015
Bacteriology has embraced the next-generation sequencing revolution, swiftly moving from the time of single genome sequencing to the age of genomic epidemiology. Hundreds and now even thousands of genomes are being sequenced for single bacterial species,
Marone, P, C. Bandi, DE MARCO, LEONE, D. Sassera, SASSERA, DAVIDE, L. D. Marco, P. Marone, COMANDATORE, FRANCESCO, Bandi, C, GAIARSA, STEFANO, F. Comandatore, S. Gaiarsa   +11 more
core   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

A systematic method for surveying data visualizations and a resulting genomic epidemiology visualization typology: GEViT

, 2018
Motivation:Data visualization is an important tool for exploring and communicating findings from genomic and healthcare datasets. Yet, without a systematic way of organizing and describing the design space of data visualizations, researchers may not be ...
Anamaria Crisan, Tamara Munzner, Jennifer L. Gardy   +2 more
core   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source