Results 71 to 80 of about 1,050,824 (300)

Current Ethical and Social Issues in Epidemiology

, 2023
The American College of Epidemiology (ACE) held its 2021 Annual Meeting virtually, September 8-10, with a conference theme of "From Womb to Tomb: Insights from Health Emergencies". The ACE Ethics Committee hosted a symposium session in recognition of the
Salerno, Jennifer, Coughlin, Steven S, Hlaing, WayWay M, Goodman, Kenneth W   +3 more
core   +1 more source

The dynamics of bla TEM resistance genes in Salmonella Typhi

Scientific Reports
Salmonella Typhi (S. Typhi) is an important pathogen causing typhoid fever worldwide. The emergence of antibiotic resistance, including that of bla TEM genes encoding to TEM $$\:\beta\:$$ -lactamases has been observed. This study aimed to investigate the
Narong Nuanmuang, Pimlapas Leekitcharoenphon, Patrick Murigu Kamau Njage, Alix Vincent Thorn, Frank M. Aarestrup   +4 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Genomic epidemiology of

Journal of Infection and Public Health
Background: Streptococcus pyogenes causes a broad spectrum of invasive and non-invasive infections globally, associated with high morbidity and mortality.
Minglei Liu, Yihua Cai, Qiaoli Xu, Zihao Dong, Chunyan Gao, Chunbao Lv, Jiaao Wang, Shangyu Tu, Wanyun Wu, Jiabao Zhu, Hui Wang, Hongbin Chen   +11 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Genomic epidemiology of Histoplasma in Africa

mBio
ABSTRACT Histoplasmosis, the disease caused by thermally dimorphic fungi in the genus Histoplasma , is usually associated with pulmonary involvement in healthy individuals and a disseminated syndrome in immunocompromised ...
Mapengo, Rutendo, Maphanga, Tsidiso, Jofre, Gaston, Rader, Jonathan, Turissini, David, Birkhead, Monica, Kwabia, S. Ama, Sepúlveda, Victoria, Buitrago, Maria José, Teixeira, Marcus de Melo, Barker, Bridget, Alanio, Alexandre, Sturny-Leclère, Aude, Garcia-Hermoso, Dea, Govender, Nelesh, Matute, Daniel   +15 more
openaire   +2 more sources

Microarrays for public health: genomic epidemiology of tuberculosis [PDF]

Comparative and Functional Genomics, 2002
AbstractIn response to a large local school‐based outbreak of tuberculosis, we have been evaluating the utility of microarray bacterial genomic analysis in outbreak management. After initial comparison of the isolate from the index case with Mycobacterium tuberculosis H37Rv, it was possible to design robust PCRs directed towards strain‐specific ...
Shafi, J, Andrew, PW, Barer, MR
openaire   +3 more sources

Genomic epidemiology of Mycobacterium tuberculosis in Wales. [PDF]

Sci Rep
Abstract Identification of factors contributing to tuberculosis (TB) transmission can guide targeted measures to reduce morbidity. Varying findings for factors associated with TB genomic clustering exist. We describe Mycobacterium tuberculosis strain diversity, drug-resistance, and ongoing transmission in Wales using single nucleotide ...
Pacchiarini N, Simkin F, Postans M, Ahern G, Song J, Brown C, Smith J, Williams C, Backx M, Thomas D, Connor TR, Williams C.   +11 more
europepmc   +4 more sources

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source