Results 11 to 20 of about 48,787 (238)

Investigating inbreeding in the turkey (Meleagris gallopavo) genome

Poultry Science, 2021
: The detrimental effects of increased homozygosity due to inbreeding have prompted the development of methods to reduce inbreeding. The detection of runs of homozygosity (ROH), or contiguous stretches of homozygous marker genotypes, can be used to ...
Sarah M. Adams, Martijn F.L. Derks, Bayode O. Makanjuola, Gabriele Marras, Ben J. Wood, Christine F. Baes   +5 more
doaj   +4 more sources

Genomic consequences of intensive inbreeding in miniature inbred pigs

BMC Genomics
Background Inbreeding, a central theme in evolutionary and conservation biology, is a crucial practice in breeding to stabilize and enhance the specific traits or to establish inbred lines.
Hong-Man Chen, Heng Zhao, Qun-Yao Zhu, Chen Yan, Ya-Qi Liu, Si Si, Muhammad Ameen Jamal, Kai-Xiang Xu, De-Ling Jiao, Min-Juan Lv, Wen Wang, Hong-Ye Zhao, Lei Chen, Ming-Shan Wang, Hong-Jiang Wei   +14 more
doaj   +3 more sources

Commonly used genomic estimators of individual inbreeding in livestock

Czech Journal of Animal Science
: Management of inbreeding is one of the crucial parts of breeding programs in livestock populations. Traditionally, the inbreeding coefficient is calculated using pedigree data; however, it can also be estimated from genomic data.
Adrián Halvoník, Nina Moravčíková, Monika Chalupková, Radovan Kasarda   +3 more
doaj   +2 more sources

Genomic partitioning of inbreeding depression in humans [PDF]

The American Journal of Human Genetics, 2021
Across species, offspring of related individuals often exhibit significant reduction in fitness-related traits, known as inbreeding depression (ID), yet the genetic and molecular basis for ID remains elusive. Here, we develop a method to quantify enrichment of ID within specific genomic annotations and apply it to human data.
Loic Yengo, Jian Yang, Matthew C. Keller, Michael E. Goddard, Naomi R. Wray, Peter M. Visscher   +5 more
openaire   +2 more sources

Genomic Inbreeding and Runs of Homozygosity Analysis of Cashmere Goat. [PDF]

Animals (Basel)
Cashmere goats are valuable genetic resources which are famous worldwide for their high-quality fiber. Runs of homozygosity (ROHs) have been identified as an efficient tool to assess inbreeding level and identify related genes under selection. However, there is limited research on ROHs in cashmere goats.
Zhao Q, Huang C, Chen Q, Su Y, Zhang Y, Wang R, Su R, Xu H, Liu S, Ma Y, Zhao Q, Ye S.   +11 more
europepmc   +4 more sources

Invited review: Inbreeding in the genomics era: Inbreeding, inbreeding depression, and management of genomic variability [PDF]

Journal of Dairy Science, 2017
Traditionally, pedigree-based relationship coefficients have been used to manage the inbreeding and degree of inbreeding depression that exists within a population. The widespread incorporation of genomic information in dairy cattle genetic evaluations allows for the opportunity to develop and implement methods to manage populations at the genomic ...
Jeremy T, Howard, Jennie E, Pryce, Christine, Baes, Christian, Maltecca   +3 more
openaire   +2 more sources

Comparison of selection methods for natural mating mass-spawning species [PDF]

, 2015
Background: Hydrocephalus in Friesian horses is a developmental disorder that often results in stillbirth of affected foals and dystocia in dams. The occurrence is probably related to a founder effect and inbreeding in the population.
Arendonk, J.A.M., van, Blonk, R.J.W., Bovenhuis, H., Haley, C.S., Komen, J., Koning, D.J., de, Massault, C.   +6 more
core   +10 more sources

Using Pedigree and Genomic Data toward Better Management of Inbreeding in Italian Dairy Sheep and Goat Breeds

Animals, 2022
The inbreeding coefficient is an important parameter for livestock management. Small ruminant breeders and associations mainly rely on pedigree information, but genomic tools are gaining relevance, overcoming possible pedigree inconsistencies. This study
Matteo Cortellari, Alessio Negro, Arianna Bionda, Silverio Grande, Alberto Cesarani, Antonello Carta, Nicola Macciotta, Stefano Biffani, Paola Crepaldi   +8 more
doaj   +1 more source

The value of genomic relationship matrices to estimate levels of inbreeding

Genetics Selection Evolution, 2021
Background Genomic relationship matrices are used to obtain genomic inbreeding coefficients. However, there are several methodologies to compute these matrices and there is still an unresolved debate on which one provides the best estimate of inbreeding.
Beatriz Villanueva, Almudena Fernández, María Saura, Armando Caballero, Jesús Fernández, Elisabeth Morales-González, Miguel A. Toro, Ricardo Pong-Wong   +7 more
doaj   +1 more source

Evaluation of inbreeding depression in Holstein cattle using whole-genome SNP markers and alternative measures of genomic inbreeding [PDF]

Journal of Dairy Science, 2013
The effects of increased pedigree inbreeding in dairy cattle populations have been well documented and result in a negative impact on profitability. Recent advances in genotyping technology have allowed researchers to move beyond pedigree analysis and study inbreeding at a molecular level.
D W, Bjelland, K A, Weigel, N, Vukasinovic, J D, Nkrumah   +3 more
openaire   +2 more sources