Journal of Animal Science and Biotechnology, 2020 Background Runs of homozygosity (ROHs) are homozygous segments of the genome where the two haplotypes inherited from the parents are identical. The current availability of genotypes for a very large number of single nucleotide polymorphisms (SNPs) is ...
Liangyu Shi +10 more
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Facial attractiveness is only weakly linked to genome–wide heterozygosity
Frontiers in Psychology, 2023 IntroductionIt has been frequently suggested that overall genomic heterozygosity and, particularly, heterozygosity of loci on the so-called major histocompatibility complex (MHC), which is responsible for the recognition of foreign substances/ pathogens ...
Martin Fieder +2 more
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Population Structure and Cryptic Relatedness in Genetic Association Studies [PDF]
, 2009 We review the problem of confounding in genetic association studies, which arises principally because of population structure and cryptic relatedness. Many treatments of the problem consider only a simple ``island'' model of population structure. We take
Astle, William, Balding, David J.
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Genomic measures of inbreeding coefficients and genome-wide scan for runs of homozygosity islands in Iranian river buffalo, Bubalus bubalis [PDF]
BMC Genetics, 2019 Abstract Background: Consecutive homozygous fragments of the genome inherited from a common ancestor to offspring are known as runs of homozygosity (ROH). ROH can be used to calculate genomic inbreeding and to identifying genomic regions that are potentially under historical selection pressure.
Seyed Mohammad Ghoreishifar +6 more
openaire +3 more sources
The German Shorthair Pointer Dog Breed (Canis lupus familiaris): Genomic Inbreeding and Variability
Animals, 2020 The German Shorthaired Pointer (GSHP) is a breed worldwide known for its hunting versatility. Dogs of this breed are appreciated as valuable companions, effective trackers, field trailers and obedience athletes. The aim of the present work is to describe
Antonio Boccardo +5 more
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Animals, 2022 Over the last century, genetic diversity in many cattle breeds has been affected by the replacement of traditional local breeds with just a few milk-producing breeds.
Ina Hulsegge +4 more
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Relationships between estimated autozygosity and complex traits in the UK Biobank [PDF]
, 2018 Inbreeding increases the risk of certain Mendelian disorders in humans but may also reduce fitness through its effects on complex traits and diseases. Such inbreeding depression is thought to occur due to increased homozygosity at causal variants that ...
Evans, Luke M +2 more
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Using Genomic Inbreeding Coefficient Estimates for Homozygosity Mapping of Rare Recessive Traits: Application to Taybi-Linder Syndrome [PDF]
The American Journal of Human Genetics, 2006 The use of inbred patients whose exact genealogy may not be available is of primary interest in mapping genes involved in rare recessive diseases. We show here that this can be achieved by estimating inbreeding coefficients from the patients' genomic information and using these estimates to perform homozygosity mapping.
Leutenegger, Anne-Louise +6 more
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Survival and divergence in a small group: The extraordinary genomic history of the endangered Apennine brown bear stragglers [PDF]
, 2017 About 100 km east of Rome, in the central Apennine Mountains, a critically endangered population of ∼50 brown bears live in complete isolation. Mating outside this population is prevented by several 100 km of bear-free territories.
Benazzo, Andrea +26 more
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Distribution of Homozygosity Regions in the Genome of Kazakh Cattle Breeds
Diversity, 2022 Runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes that are passed from parents to their offspring. ROHs are suitable for determining population history, inbreeding rates, and the genetic relationships between individuals in the ...
Indira Beishova +7 more
doaj +1 more source